Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B14 | Q9BPX1 | 3/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.34 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.34 |
| ▸ | TTR | P02766 | 3/20 | 0.33 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | KRAS | P01116 | 2/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | PLG | P00747 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
| ▸ | KLK1 | P06870 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16502418 | 0.86 | TTR (0.48) | HSD17B14TTRPLA2G2DKDM4EMAPT | |
| SCHEMBL16503576 | 0.83 | HSP90AA1 (0.35) | CTDSP1HSD17B1HSD17B2TTRCYP1A2 | |
| SCHEMBL7916817 | 0.82 | AKR1C3 (0.41) | PLA2G2DCYP1A2F2PLGPLAU | |
| SCHEMBL7916813 | 0.81 | KRAS (0.33) | TTRPLA2G2DKRAS | |
| SCHEMBL7919040 | 0.79 | LCK (0.46) | KDM4EMAPTMEN1KMT2ARAB9A | |
| SCHEMBL7915836 | 0.77 | GRM2 (0.35) | PLA2G2DF2PLGPLAUPLAT | |
| SCHEMBL7918327 | 0.77 | HTR5A (0.54) | — | |
| SCHEMBL7918210 | 0.77 | PLA2G2D (0.52) | TTRPLA2G2DMEN1KMT2ARAB9A | |
| SCHEMBL7916525 | 0.76 | AKR1C3 (0.41) | HSD17B1HSD17B2TTRPLA2G2DCYP1A2 | |
| SCHEMBL16496916 | 0.75 | ESR1 (0.37) | HSD17B14KDM4EMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010090304-A1 | ACYLGUANIDINE DERIVATIVE | アステラス製薬株式会社 (JP) | 2010-08-12 | — | — | WO | disclosed |