Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HTR5A | P47898 | 1/20 | 0.32 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | PLG | P00747 | 1/20 | 0.30 |
| ▸ | PLAU | P00749 | 1/20 | 0.30 |
| ▸ | PLAT | P00750 | 1/20 | 0.30 |
| ▸ | KLK1 | P06870 | 1/20 | 0.30 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16502660 | 0.87 | PLA2G2D (0.45) | GRM2THRATHRBHTR5APLA2G2D | |
| SCHEMBL7916835 | 0.81 | PDE2A (0.35) | HTR5AMAPTPDE10APLAU | |
| SCHEMBL16502659 | 0.81 | PDK2 (0.40) | PDK2MAPT | |
| SCHEMBL7915672 | 0.79 | HTR5A (0.53) | HTR5A | |
| SCHEMBL7916525 | 0.79 | AKR1C3 (0.41) | PLA2G2DRORCF2PLGPLAU | |
| SCHEMBL7918472 | 0.77 | HSD17B14 (0.36) | THRBPLA2G2DMAPTF2PLG | |
| SCHEMBL16503576 | 0.77 | HSP90AA1 (0.35) | THRATHRBTRPV1MAPTF2 | |
| SCHEMBL7915822 | 0.77 | PLA2G2D (0.50) | HTR5APLA2G2DTRPV1RORC | |
| SCHEMBL7918345 | 0.76 | CYP1A2 (0.40) | TRPV1RORCF2PLGPLAU | |
| SCHEMBL7916817 | 0.76 | AKR1C3 (0.41) | PLA2G2DMAPTF2PLGPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010090304-A1 | ACYLGUANIDINE DERIVATIVE | アステラス製薬株式会社 (JP) | 2010-08-12 | — | — | WO | disclosed |