SCHEMBL16503737

SCHEMBL16503737

Cc1cc(C#N)cc(C(=O)NC(C)(C)C)c1NC(=O)c1sc(Cn2nnc(C(F)(F)F)n2)nc1-c1ccccc1Cl

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 3/20 0.36
▸ NPC1 O15118 1/20 0.36
▸ RAB9A P51151 1/20 0.36
▸ L3MBTL1 Q9Y468 1/20 0.36
▸ SLC2A1 P11166 12/20 0.35
▸ SLC2A3 P11169 12/20 0.35
▸ SLC2A4 P14672 12/20 0.35
▸ SLC2A2 P11168 4/20 0.33
▸ POLB P06746 2/20 0.32
▸ MAPT P10636 2/20 0.32
▸ DGAT2 Q96PD7 1/20 0.32
▸ SMN1; SMN2 Q16637 3/20 0.32
▸ NPSR1 Q6W5P4 1/20 0.32
▸ EPAS1 Q99814 1/20 0.32
▸ ALDH1A1 P00352 3/20 0.32
▸ TSHR P16473 2/20 0.32
▸ KDM4E B2RXH2 1/20 0.31
▸ MEN1 O00255 1/20 0.31
▸ ALOX15 P16050 1/20 0.31
▸ NPY1R P25929 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16503733 0.93 SLC2A1 (0.37) HPGDSLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL16503762 0.92 HPGD (0.39) HPGDNPC1RAB9AL3MBTL1DGAT2
SCHEMBL16503760 0.92 SLC2A1 (0.35) HPGDSLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL16503761 0.90 HPGD (0.37) HPGDNPC1RAB9AL3MBTL1MAPT
SCHEMBL16503746 0.90 SLC2A1 (0.36) HPGDNPC1RAB9AL3MBTL1SLC2A1
SCHEMBL16503749 0.85 EPAS1 (0.37) HPGDNPC1RAB9AL3MBTL1SLC2A1
SCHEMBL16503758 0.85 F10 (0.36) HPGDNPC1RAB9AL3MBTL1POLB
SCHEMBL16503722 0.84 SLC2A1 (0.35) HPGDNPC1RAB9AL3MBTL1SLC2A1
SCHEMBL16503732 0.83 F10 (0.35) HPGDNPC1RAB9AL3MBTL1SLC2A1
SCHEMBL16503727 0.83 MAPT (0.34) HPGDNPC1RAB9AL3MBTL1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8980886-B2 Anthranilic acid derivatives BAYER CROPSCIENCE AG (DE) 2015-03-17 — — US disclosed
US-8980886-B2 Anthranilic acid derivatives BAYER CROPSCIENCE AG (DE) 2015-03-17 — — US disclosed
US-20110312953-A1 ANTHRANILIC ACID DERIVATIVES BAYER CROPSCIENCE AG (DE) 2011-12-22 — — US disclosed
US-20110312953-A1 ANTHRANILIC ACID DERIVATIVES BAYER CROPSCIENCE AG (DE) 2011-12-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110312953-A1 ANTHRANILIC ACID DERIVATIVES ANTXR2, NQO2, ACLY HPGD 2834/4885NPC1 4635/4885RAB9A 231/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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