SCHEMBL16503749

SCHEMBL16503749

Cc1cc(C#N)cc(C(=O)NC(C)(C)C)c1NC(=O)c1cnc(Cn2nnc(C(F)(F)F)n2)nc1-c1ccccc1Cl

nearest known ligand 0.37

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ EPAS1 Q99814 1/20 0.37
▸ SLC2A1 P11166 15/20 0.36
▸ SLC2A3 P11169 15/20 0.36
▸ SLC2A4 P14672 15/20 0.36
▸ SLC2A2 P11168 6/20 0.35
▸ NPC1 O15118 1/20 0.34
▸ HPGD P15428 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ NTRK1 P04629 1/20 0.34
▸ PDE4A P27815 2/20 0.33
▸ PDE4B Q07343 2/20 0.33
▸ PDE4C Q08493 2/20 0.33
▸ PDE4D Q08499 2/20 0.33
▸ PDE3B Q13370 1/20 0.33
▸ PDE11A Q9HCR9 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16503751 0.93 EPAS1 (0.38) EPAS1SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL16503752 0.92 SLC2A1 (0.41) EPAS1SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL16503753 0.92 EPAS1 (0.41) EPAS1NPC1HPGDRAB9AL3MBTL1
SCHEMBL16503763 0.92 EPAS1 (0.37) EPAS1SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL16572256 0.88 EPAS1 (0.35) EPAS1SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL16503737 0.85 HPGD (0.36) EPAS1SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL1696948 0.85 EPAS1 (0.42) EPAS1NTRK1PDE4APDE4BPDE4C
SCHEMBL16503738 0.83 EPAS1 (0.44) EPAS1SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL16503748 0.83 EPAS1 (0.41) EPAS1NTRK1PDE4APDE4BPDE4C
SCHEMBL16503722 0.83 SLC2A1 (0.35) SLC2A1SLC2A3SLC2A4SLC2A2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8980886-B2 Anthranilic acid derivatives BAYER CROPSCIENCE AG (DE) 2015-03-17 — — US disclosed
US-8980886-B2 Anthranilic acid derivatives BAYER CROPSCIENCE AG (DE) 2015-03-17 — — US disclosed
US-20110312953-A1 ANTHRANILIC ACID DERIVATIVES BAYER CROPSCIENCE AG (DE) 2011-12-22 — — US disclosed
US-20110312953-A1 ANTHRANILIC ACID DERIVATIVES BAYER CROPSCIENCE AG (DE) 2011-12-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110312953-A1 ANTHRANILIC ACID DERIVATIVES ANTXR2, NQO2, ACLY EPAS1 3339/4885SLC2A1 4190/4885SLC2A3 4342/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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