Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Morinamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morinamide SCHEMBL563960 | 0.99 | GFER (0.67) | GFERALDH1A1KDM4ETAAR1NPC1 | |
| Morinamide SCHEMBL29464523 | 0.99 | GFER (0.67) | GFERALDH1A1KDM4ETAAR1NPC1 | |
| Morinamide SCHEMBL1650433 | 0.97 | GFER (0.66) | GFERALDH1A1KDM4ETAAR1NPC1 | |
| SCHEMBL26922576 | 0.85 | SMN1; SMN2 (0.55) | ALDH1A1NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL29834822 | 0.85 | SMN1; SMN2 (0.55) | ALDH1A1NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL26921832 | 0.85 | GFER (0.67) | GFERALDH1A1KDM4ETAAR1NPC1 | |
| SCHEMBL29834783 | 0.85 | GFER (0.67) | GFERALDH1A1KDM4ETAAR1NPC1 | |
| SCHEMBL31086880 | 0.83 | SMN1; SMN2 (0.64) | ALDH1A1KDM4ETSHRSMN1; SMN2 | |
| SCHEMBL26921315 | 0.83 | SMN1; SMN2 (0.64) | ALDH1A1KDM4ETSHRSMN1; SMN2 | |
| SCHEMBL29834871 | 0.82 | GFER (0.64) | GFERALDH1A1KDM4ETAAR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025027535-A1 | EXTRACTS OF SANICULA ELATA FOR USE IN TREATING PULMONARY TUBERCULOSIS | WALTER SISULU UNIVERSITY (ZA) | 2025-02-06 | — | — | WO | claimed |
| WO-2025027535-A1 | EXTRACTS OF SANICULA ELATA FOR USE IN TREATING PULMONARY TUBERCULOSIS | WALTER SISULU UNIVERSITY (ZA) | 2025-02-06 | — | — | WO | disclosed |
| US-7989004-B2 | Antitubercular extracts of Salicornia brachiata | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2011-08-02 | — | — | US | disclosed |
| US-7442393-B2 | Herbal extracts of Salicornia species, process of preparation thereof, use thereof against tuberculosis | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2008-10-28 | — | — | US | disclosed |
| EP-1948316-A1 | ENHANCEMENT OF ANTITUBERCULAR ACTIVITY OF EXTRACTS OF SALICORNIA BRACHIATA | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2008-07-30 | — | — | EP | disclosed |
| EP-1684778-B1 | HERBAL EXTRACTS OF SALICORNIA SPECIES, PROCESS OF PREPARATION THEREOF, USE THEREOF AGAINST TUBERCULOSIS | COUNCIL SCIENT IND RES (IN) | 2008-07-23 | — | — | EP | disclosed |
| US-20070248704-A1 | Herbal extracts of salicornia species, process of preparation thereof, use thereof against tuberculosis | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2007-10-25 | — | — | US | disclosed |
| US-20070020351-A1 | Antitubercular extracts of Salicornia brachiata | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2007-01-25 | — | — | US | disclosed |
| EP-1684778-A1 | HERBAL EXTRACTS OF SALICORNIA SPECIES, PROCESS OF PREPARATION THEREOF, USE THEREOF AGAINST TUBERCULOSIS | Council of Scientific and Industrial Research (IN) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005115424-A1 | ENHANCEMENT OF ANTITUBERCULAR ACTIVITY OF EXTRACTS OF SALICORNIA BRACHIATA | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2005-12-08 | — | — | WO | disclosed |
| US-20050186291-A1 | Herbal extracts of salicornia species, process of preparation thereof, use thereof against tuberculosis | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH | 2005-08-25 | — | — | US | disclosed |
| WO-2005021020-A1 | HERBAL EXTRACTS OF SALICORNIA SPECIES, PROCESS OF PREPARATION THEREOF, USE THEREOF AGAINST TUBERCULOSIS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2005-03-10 | — | — | WO | disclosed |