Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | F2R | P25116 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16512320 | 1.00 | CHRNA7 (0.38) | CHRNA7MAPTLMNACHRM2ADRA2A | |
| SCHEMBL25259435 | 0.86 | CHRNA7 (0.39) | CHRNA7MAPTLMNACHRM2ADRA2A | |
| SCHEMBL16512570 | 0.80 | LMNA (0.33) | CHRNA7MAPTLMNACHRM2ADRA2A | |
| SCHEMBL16512537 | 0.80 | LMNA (0.33) | CHRNA7MAPTLMNACHRM2ADRA2A | |
| SCHEMBL16512357 | 0.78 | LMNA (0.33) | CHRNA7MAPTLMNACHRM2ADRA2A | |
| SCHEMBL2304458 | 0.77 | CHRNA7 (0.38) | CHRNA7MAPTLMNACHRM2ADRA2A | |
| SCHEMBL2304454 | 0.77 | CHRNA7 (0.38) | CHRNA7MAPTLMNACHRM2ADRA2A | |
| SCHEMBL19199719 | 0.73 | SIGMAR1 (0.39) | CHRNA7MAPTLMNACHRM2ADRA2A | |
| SCHEMBL19198986 | 0.73 | SIGMAR1 (0.39) | CHRNA7MAPTLMNACHRM2ADRA2A | |
| SCHEMBL22770864 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011162562-A2 | [6+5] FUSED BICYCLES AS A THROMBIN ANTAGONIST, PROCESS FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE BICYCLES | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-12-29 | — | — | WO | disclosed |