Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KDM6B | O15054 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 5/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.32 |
| ▸ | CDC42BPB | Q9Y5S2 | 3/20 | 0.32 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13734858 | 0.79 | NAMPT (0.34) | NAMPT | |
| SCHEMBL13735091 | 0.79 | NAMPT (0.32) | NAMPT | |
| SCHEMBL15874793 | 0.77 | KDM4E (0.35) | KDM4EALDH1A1MEN1KDM6BKDM4A | |
| SCHEMBL15874745 | 0.75 | KDM4E (0.33) | KDM4EALDH1A1MEN1KDM6BKDM4A | |
| SCHEMBL15874843 | 0.75 | KDM4E (0.33) | KDM4EALDH1A1MEN1KDM6BKDM4A | |
| SCHEMBL16515363 | 0.74 | ALDH1A1 (0.39) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL15874968 | 0.74 | NAMPT (0.34) | KDM4EALDH1A1MEN1KDM6BKDM4A | |
| SCHEMBL4011286 | 0.71 | SLC6A9 (0.50) | HSD17B10SLC6A9 | |
| SCHEMBL22981916 | 0.70 | SLC6A9 (0.41) | KDM4EALDH1A1MAPTTDP1GAA | |
| SCHEMBL15879994 | 0.69 | CHEK1 (0.33) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3036238-A1 | FURO- AND THIENO-PYRIDINE CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | Incyte Corporation (US) | 2016-06-29 | — | — | EP | disclosed |
| WO-2016010897-A1 | BICYCLIC HETEROAROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE CORPORATION (US) | 2016-01-21 | — | — | WO | disclosed |
| WO-2015027124-A1 | FURO- AND THIENO-PYRIDINE CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE CORPORATION (US) | 2015-02-26 | — | — | WO | disclosed |