Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 8/20 | 0.62 |
| ▸ | PRCP | P42785 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | CD44 | P16070 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16518079 | 0.90 | PRCP (0.61) | PNMTPRCPADRA2AADRA2BADRA2C | |
| SCHEMBL16518150 | 0.83 | PNMT (0.50) | PNMTPRCPADRA2AADRA2BADRA2C | |
| SCHEMBL16518156 | 0.83 | PNMT (0.46) | PNMTPRCPADRA2AADRA2BADRA2C | |
| SCHEMBL16518137 | 0.83 | PRCP (0.54) | PNMTPRCPADRA2AADRA2BADRA2C | |
| SCHEMBL14677593 | 0.80 | PNMT (0.72) | PNMTPRCPADRA2AADRA2BADRA2C | |
| SCHEMBL16518783 | 0.80 | PNMT (0.54) | PNMTPRCPHTR2CHTR2AHTR2B | |
| SCHEMBL16518022 | 0.79 | PRCP (0.56) | PNMTPRCPADRA2AADRA2BADRA2C | |
| SCHEMBL16518013 | 0.79 | PRCP (0.59) | PNMTPRCPADRA2AADRA2BADRA2C | |
| SCHEMBL1852509 | 0.78 | PNMT (1.00) | PNMTPRCPADRA2AADRA2BADRA2C | |
| SCHEMBL3052029 | 0.78 | PNMT (0.61) | PNMTPRCPADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2671869-B1 | TETRAHYDROISOQUINOLINE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2015-11-04 | — | — | EP | disclosed |
| US-8962612-B2 | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC. (JP) | 2015-02-24 | — | — | US | disclosed |
| US-8962612-B2 | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC. (JP) | 2015-02-24 | — | — | US | disclosed |