Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 6/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | HTR5A | P47898 | 1/20 | 0.35 |
| ▸ | PRCP | P42785 | 1/20 | 0.34 |
| ▸ | CD44 | P16070 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16518150 | 0.91 | PNMT (0.50) | PNMTTAAR1HTR2CHTR2AHTR2B | |
| SCHEMBL16518153 | 0.90 | HTR5A (0.41) | PNMTHTR2CHTR2AHTR2BHTR5A | |
| SCHEMBL16517992 | 0.85 | PNMT (0.49) | PNMTTAAR1HTR2CHTR2AHTR2B | |
| SCHEMBL16518158 | 0.83 | HTR5A (0.38) | PNMTHTR5APRCPCD44 | |
| SCHEMBL16518136 | 0.83 | PNMT (0.62) | PNMTTAAR1HTR2CHTR2AHTR2B | |
| SCHEMBL16518157 | 0.82 | PNMT (0.45) | PNMTTAAR1HTR2CHTR2AHTR2B | |
| SCHEMBL16518185 | 0.81 | HTR2C (0.37) | PNMTHTR2CHTR2AHTR2BADRA2A | |
| SCHEMBL16518144 | 0.80 | PNMT (0.43) | PNMTTAAR1HTR2CHTR2AHTR2B | |
| SCHEMBL16518755 | 0.80 | PNMT (0.45) | PNMT | |
| SCHEMBL16518155 | 0.77 | HTR7 (0.47) | PNMTTAAR1HTR2CHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962612-B2 | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC. (JP) | 2015-02-24 | — | — | US | disclosed |
| US-8962612-B2 | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC. (JP) | 2015-02-24 | — | — | US | disclosed |