Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 1/20 | 0.56 |
| ▸ | PNMT | P11086 | 7/20 | 0.49 |
| ▸ | CD44 | P16070 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16518079 | 0.89 | PRCP (0.61) | PRCPPNMTCD44MAOBADRA2A | |
| SCHEMBL16518127 | 0.84 | PRCP (0.55) | PRCPPNMTCD44MAOBADRA2A | |
| SCHEMBL16518132 | 0.80 | PRCP (0.58) | PRCPPNMTCD44MAOBADRA2A | |
| SCHEMBL16518136 | 0.79 | PNMT (0.62) | PRCPPNMTCD44MAOBADRA2A | |
| SCHEMBL16518137 | 0.79 | PRCP (0.54) | PRCPPNMTCD44MAOBADRA2A | |
| SCHEMBL16518189 | 0.79 | PRCP (0.50) | PRCPPNMTCD44MAOBHTR2C | |
| SCHEMBL16518013 | 0.78 | PRCP (0.59) | PRCPPNMTCD44MAOBADRA2A | |
| SCHEMBL16518152 | 0.78 | HTR5A (0.42) | PNMTHTR2AHTR2CHTR2B | |
| SCHEMBL3052029 | 0.77 | PNMT (0.61) | PRCPPNMTCD44MAOBADRA2A | |
| SCHEMBL16518783 | 0.76 | PNMT (0.54) | PRCPPNMTHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2671869-B1 | TETRAHYDROISOQUINOLINE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2015-11-04 | — | — | EP | disclosed |
| US-8962612-B2 | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC. (JP) | 2015-02-24 | — | — | US | disclosed |
| US-8962612-B2 | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC. (JP) | 2015-02-24 | — | — | US | disclosed |