Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 4/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16518755 | 0.89 | PNMT (0.45) | PNMTCD274RPS6KA2HTR6LRRK2 | |
| SCHEMBL16517992 | 0.87 | PNMT (0.49) | PNMTHTR2AHTR2CHTR2BHTR6 | |
| SCHEMBL16518150 | 0.84 | PNMT (0.50) | PNMTHTR2AHTR2CHTR2BHTR7 | |
| SCHEMBL16518144 | 0.84 | PNMT (0.43) | PNMTCD274HTR2AHTR2CHTR2B | |
| SCHEMBL16518783 | 0.81 | PNMT (0.54) | PNMTCD274HTR2AHTR2CHTR2B | |
| SCHEMBL16518146 | 0.80 | PNMT (0.41) | PNMTHTR6HTR7ADRA2AADRA2B | |
| SCHEMBL16518156 | 0.77 | PNMT (0.46) | PNMTHTR2AHTR2CHTR2BADRA2A | |
| SCHEMBL16518148 | 0.76 | PNMT (0.45) | PNMTHTR2AHTR2CHTR2BHTR7 | |
| SCHEMBL16518080 | 0.75 | HTR2C (0.53) | PNMTHTR2AHTR2CHTR2BHTR6 | |
| SCHEMBL16518141 | 0.75 | PNMT (0.46) | PNMTHTR2AHTR2CHTR2BHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2671869-B1 | TETRAHYDROISOQUINOLINE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2015-11-04 | — | — | EP | disclosed |
| US-8962612-B2 | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC. (JP) | 2015-02-24 | — | — | US | disclosed |