Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.41 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16518773 | 0.89 | PNMT (0.42) | PNMTCD274RPS6KA2HTR6LRRK2 | |
| SCHEMBL16518153 | 0.86 | HTR5A (0.41) | PNMTHTR7 | |
| SCHEMBL16518783 | 0.84 | PNMT (0.54) | PNMTCD274RPS6KA2 | |
| SCHEMBL16518158 | 0.82 | HTR5A (0.38) | PNMTCD274HTR6HTR7 | |
| SCHEMBL16518156 | 0.80 | PNMT (0.46) | PNMT | |
| SCHEMBL16518020 | 0.78 | HTR2C (0.45) | PNMTCD274HTR6HTR7 | |
| SCHEMBL16518162 | 0.76 | PARP1 (0.36) | PNMTCD274HTR6HTR7 | |
| SCHEMBL16518155 | 0.74 | HTR7 (0.47) | PNMTHTR6HTR7 | |
| Hydrochloric Acid SCHEMBL38653786 | 0.74 | HTR2C (0.44) | PNMTCD274HTR6HTR7 | |
| SCHEMBL16518746 | 0.73 | CYP11B1 (0.44) | PNMTCD274HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2671869-B1 | TETRAHYDROISOQUINOLINE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2015-11-04 | — | — | EP | disclosed |
| US-8962612-B2 | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC. (JP) | 2015-02-24 | — | — | US | disclosed |