Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.67 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.67 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.67 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 13/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 13/20 | 0.44 |
| ▸ | MAPT | P10636 | 12/20 | 0.44 |
| ▸ | HTT | P42858 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1792641 | 0.80 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGMEN1 | |
| SCHEMBL14053013 | 0.78 | PIK3CD (0.80) | PIK3CDPIK3CAPIK3CBPIK3CGMEN1 | |
| SCHEMBL20644802 | 0.76 | PIK3CD (0.73) | PIK3CDPIK3CAPIK3CBPIK3CGMEN1 | |
| SCHEMBL22225700 | 0.76 | PIK3CD (0.76) | PIK3CDPIK3CAPIK3CBPIK3CGMEN1 | |
| SCHEMBL1790968 | 0.75 | PIK3CD (0.77) | PIK3CDPIK3CAPIK3CBPIK3CGMEN1 | |
| SCHEMBL22225674 | 0.74 | PIK3CD (0.74) | PIK3CDPIK3CAPIK3CBPIK3CGMEN1 | |
| SCHEMBL22225686 | 0.74 | PIK3CD (0.70) | PIK3CDPIK3CAPIK3CBPIK3CGMEN1 | |
| SCHEMBL22225697 | 0.72 | PIK3CD (0.61) | PIK3CDPIK3CAPIK3CBPIK3CGMEN1 | |
| SCHEMBL22225682 | 0.72 | PIK3CG (0.69) | PIK3CDPIK3CAPIK3CBPIK3CGMEN1 | |
| SCHEMBL1791900 | 0.71 | MEN1 (0.72) | PIK3CDPIK3CAPIK3CBPIK3CGMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150056191-A1 | IGF1 BIOMARKER FOR IGF1R INHIBITOR THERAPY | MERCK SHARP & DOHME CORP. | 2015-02-26 | — | — | US | disclosed |
| US-20150056191-A1 | IGF1 BIOMARKER FOR IGF1R INHIBITOR THERAPY | MERCK SHARP & DOHME CORP. | 2015-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150056191-A1 | IGF1 BIOMARKER FOR IGF1R INHIBITOR THERAPY | IGF1R, IGFBP1, IGF2BP2 | PIK3CD 1926/4885PIK3CA 607/4885PIK3CB 1304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.