Idraparinux

SCHEMBL1652150

CO[C@H]1O[C@H](COS(=O)(=O)[O-])[C@@H](O[C@@H]2O[C@@H](C(=O)[O-])[C@@H](O[C@H]3O[C@H](COS(=O)(=O)[O-])[C@@H](O[C@@H]4O[C@H](C(=O)[O-])[C@@H](O[C@H]5O[C@H](COS(=O)(=O)[O-])[C@@H](OC)[C@H](OC)[C@H]5OC)[C@H](OC)[C@H]4OC)[C@H](OS(=O)(=O)[O-])[C@H]3OS(=O)(=O)[O-])[C@H](OC)[C@H]2OC)[C@H](OS(=O)(=O)[O-])[C@H]1OS(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

F10

The experimentally established mechanism targets of Idraparinux. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 5)

	gene	UniProt	supporting neighbours	confidence
▸	F10 known ✓	P00742	4/20	0.87

▸	SERPINC1	P01008	3/20	1.00

▸	F2	P00734	1/20	0.81

▸	FGF1	P05230	3/20	0.79

▸	HPSE	Q9Y251	10/20	0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Idraparinux SCHEMBL427808	0.78	SERPINC1 (0.85)	SERPINC1F10F2FGF1HPSE
SCHEMBL29407493	0.78	SERPINC1 (0.85)	SERPINC1F10F2FGF1HPSE
Idraparinux SCHEMBL29382311	0.78	SERPINC1 (0.85)	SERPINC1F10F2FGF1HPSE
SCHEMBL7334212	0.74	HPSE (0.85)	SERPINC1FGF1HPSE
SCHEMBL12458587	0.73	SERPINC1 (0.75)	SERPINC1F10F2FGF1HPSE
SCHEMBL12729453	0.71	SERPINC1 (0.74)	SERPINC1F10F2FGF1HPSE
SCHEMBL17660081	0.70	SERPINC1 (0.66)	SERPINC1F10F2FGF1HPSE
SCHEMBL29436055	0.70	FGF1 (0.60)	SERPINC1F10F2FGF1HPSE
SCHEMBL16316488	0.70	FGF1 (0.64)	SERPINC1F10FGF1HPSE
SCHEMBL13551204	0.68	SERPINC1 (0.66)	SERPINC1F10F2FGF1HPSE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
CN-111172098-B	Use of compounds containing a single pentasaccharide building block in cell culture	未来智人再生医学研究院(广州)有限公司	2022-07-01	—	—	CN	disclosed
US-7927613-B2	Pharmaceutical co-crystal compositions	UNIVERSITY OF SOUTH FLORIDA (US)	2011-04-19	—	—	US	disclosed
US-7790905-B2	Pharmaceutical propylene glycol solvate compositions	MCNEIL-PPC, INC. (US)	2010-09-07	—	—	US	disclosed