Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MLYCD | O95822 | 2/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21514118 | 0.83 | CYP2D6 (0.46) | CYP2D6CYP2C19MLYCDMMP1MMP8 | |
| SCHEMBL30747967 | 0.78 | PI4KB (0.34) | MLYCDMMP1MMP8CTSSCTSK | |
| SCHEMBL18011825 | 0.78 | ALDH1A1 (0.35) | LMNACTSSCTSKTDP1MAPT | |
| SCHEMBL19183160 | 0.77 | HIF1A (0.37) | CTSSCTSKGAAALDH1A1PI4KB | |
| SCHEMBL26319464 | 0.77 | MLYCD (0.35) | MLYCDMMP1MMP8LMNACTSS | |
| SCHEMBL15257158 | 0.76 | CYP2D6 (0.52) | CYP2D6CYP2C19MLYCDMMP1MMP8 | |
| SCHEMBL9462919 | 0.76 | CYP2D6 (0.52) | CYP2D6CYP2C19MLYCDMMP1MMP8 | |
| SCHEMBL20805872 | 0.75 | CYP2C19 (0.46) | CYP2D6CYP2C19MLYCDMMP1MMP8 | |
| SCHEMBL12778328 | 0.73 | CYP2D6 (0.54) | CYP2D6CYP2C19MLYCDMMP1MMP8 | |
| SCHEMBL9462565 | 0.72 | MAPK1 (0.49) | CYP2D6CYP2C19MMP1MMP8HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9758492-B2 | IDO inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-09-12 | — | — | US | disclosed |
| US-9758492-B2 | IDO inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-09-12 | — | — | US | disclosed |
| EP-3039020-B1 | IDO INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-07-19 | — | — | EP | disclosed |
| EP-3039020-B1 | IDO INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-07-19 | — | — | EP | disclosed |
| US-20160200674-A1 | IDO INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-07-14 | — | — | US | disclosed |
| US-20160200674-A1 | IDO INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-07-14 | — | — | US | disclosed |
| EP-3039020-A1 | IDO INHIBITORS | Bristol-Myers Squibb Company (US) | 2016-07-06 | — | — | EP | disclosed |
| CN-105658643-A | Ido inhibitors | 百时美施贵宝公司 | 2016-06-08 | — | — | CN | disclosed |
| WO-2015031295-A1 | IDO INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-03-05 | — | — | WO | disclosed |
| WO-2015031295-A1 | IDO INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160200674-A1 | IDO INHIBITORS | IDO1, IDO2, INMT | CYP2D6 844/4885CYP2C19 1582/4885MLYCD 629/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.