SCHEMBL16550652

SCHEMBL16550652

O=C(O)/C(Cc1ccccc1)=C(\CC1CO1)C(=O)O

nearest known ligand 0.50

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 2/20 0.50
CES2 O00748 1/20 0.44
CES1 P23141 1/20 0.44
AKR1B1 P15121 1/20 0.44
CTBP2 P56545 1/20 0.41
EPHX2 P34913 1/20 0.39
HPGD P15428 1/20 0.39
FAAH O00519 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16550684 1.00 MGLL (0.50) MGLLCES2CES1AKR1B1CTBP2
SCHEMBL3881031 0.81 CES1 (0.64) CES2CES1AKR1B1CTBP2EPHX2
SCHEMBL384895 0.81 CES1 (0.64) CES2CES1AKR1B1CTBP2EPHX2
SCHEMBL384894 0.81 CES1 (0.64) CES2CES1AKR1B1CTBP2EPHX2
SCHEMBL9005190 0.81 ALDH1A1 (0.33)
SCHEMBL7583674 0.81 ALDH1A1 (0.33)
SCHEMBL11165844 0.81 ALDH1A1 (0.33)
SCHEMBL304071 0.79 CES1 (0.61) CES2CES1AKR1B1CTBP2EPHX2
SCHEMBL304073 0.79 CES1 (0.61) CES2CES1AKR1B1CTBP2EPHX2
SCHEMBL9355594 0.77 NPC1 (0.55) CES2CES1AKR1B1EPHX2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3041884-B1 RADICAL CROSS-LINKING OF POLYETHER CARBONATE POLYOLS CONTAINING LOW ELECTRON AND ELECTRON-RICH DOUBLE BONDS COVESTRO DEUTSCHLAND AG (DE) 2018-03-21 EP disclosed
EP-3041884-A1 RADICAL CROSSLINKING OF POLYETHER CARBONATE POLYOLS THAT HAVE ELECTRON-POOR AND ELECTRON-RICH DOUBLE BONDS Covestro Deutschland AG (DE) 2016-07-13 EP disclosed
WO-2015032737-A1 RADICAL CROSSLINKING OF POLYETHER CARBONATE POLYOLS THAT HAVE ELECTRON-POOR AND ELECTRON-RICH DOUBLE BONDS BAYER MATERIALSCIENCE AG (DE) 2015-03-12 WO disclosed
EP-2845873-A1 Radical cross-linking of polyether carbonate polyols containing low electron and electron-rich double bonds Bayer MaterialScience AG (DE) 2015-03-11 EP disclosed