Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16552191 | 0.89 | KDM4A (0.40) | KDM4AHTTL3MBTL1BRD4MAPKAPK2 | |
| SCHEMBL16551995 | 0.82 | KDM4A (0.41) | KDM4AATRL3MBTL1MAPKAPK2KDM4E | |
| SCHEMBL26093437 | 0.82 | KDM4A (0.41) | KDM4AATRL3MBTL1MAPKAPK2KDM4E | |
| SCHEMBL16552171 | 0.82 | KDM4A (0.34) | KDM4AHTTL3MBTL1BRD4MAPKAPK2 | |
| SCHEMBL16552097 | 0.80 | KDM4A (0.36) | KDM4AHTTL3MBTL1BRD4MAPKAPK2 | |
| SCHEMBL17922712 | 0.80 | PDE5A (0.38) | L3MBTL1POLB | |
| SCHEMBL31084548 | 0.80 | KDM4A (0.39) | KDM4AATRL3MBTL1BRD4MAPKAPK2 | |
| SCHEMBL26094198 | 0.80 | KDM4A (0.39) | KDM4AATRL3MBTL1BRD4MAPKAPK2 | |
| SCHEMBL16551971 | 0.78 | L3MBTL1 (0.43) | KDM4AHTTATRL3MBTL1KDM4E | |
| SCHEMBL20834068 | 0.78 | SSTR4 (0.33) | KDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3042913-B1 | CYCLIC PEPTIDE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | HANGZHOU GUANYU BIO MEDICAL CO LTD (CN) | 2019-03-20 | — | — | EP | disclosed |
| EP-3042913-A1 | CYCLIC PEPTIDE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Hangzhou Guanyu Bio-Medical Co., Ltd (CN) | 2016-07-13 | — | — | EP | disclosed |
| WO-2015027959-A1 | CYCLIC PEPTIDE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | 上海冠宇生物医药科技有限公司 (CN) | 2015-03-05 | — | — | WO | disclosed |