SCHEMBL16554154

SCHEMBL16554154

CC1(C)OB(c2ccc(CO[Si](C)(C)C(C)(C)C)nc2)OC1(C)C

nearest known ligand 0.55

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 2/20 0.47
FFAR1 O14842 1/20 0.38
LPL P06858 9/20 0.38
LIPG Q9Y5X9 9/20 0.38
AAK1 Q2M2I8 2/20 0.36
USP30 Q70CQ3 1/20 0.36
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA9 Q16790 1/20 0.35
F11 P03951 1/20 0.34
HIF1A Q16665 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29520942 1.00 DGAT1 (0.47) DGAT1FFAR1LPLLIPGAAK1
SCHEMBL14873045 0.84 DGAT1 (0.49) DGAT1FFAR1LPLLIPGCA1
SCHEMBL1180716 0.83 DGAT1 (0.48) DGAT1FFAR1LPLLIPGAAK1
SCHEMBL27088182 0.83 DGAT1 (0.41) DGAT1FFAR1LPLLIPGAAK1
SCHEMBL21721888 0.80 DGAT1 (0.50) DGAT1FFAR1LPLLIPGAAK1
SCHEMBL10249044 0.80 DGAT1 (0.56) DGAT1FFAR1LPLLIPGAAK1
SCHEMBL2486269 0.80 DGAT1 (0.46) DGAT1FFAR1LPLLIPGCA1
SCHEMBL27095110 0.80 DGAT1 (0.36) DGAT1FFAR1LPLLIPGAAK1
SCHEMBL19329278 0.79 DGAT1 (0.48) DGAT1FFAR1LPLLIPGUSP30
SCHEMBL25066062 0.78 DGAT1 (0.46) DGAT1FFAR1LPLLIPGAAK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230137025-A1 SUBSTITUTED IMIDAZO[1,2-c]PYRIMIDINES AS PRC2 INHIBITORS Mirati Therapeutics, Inc. 2023-05-04 US disclosed
US-11220509-B2 Substituted imidazo[1,2-c]pyrimidines as PRC2 inhibitors Mirati Therapeutics, Inc. (US) 2022-01-11 US disclosed
US-11091495-B2 Substituted imidazo[1,2-c]pyrimidines as PRC2 inhibitors Mirati Therapeutics, Inc. (US) 2021-08-17 US disclosed
US-20210230168-A1 PRC2 INHIBITORS Mirati Therapeutics, Inc. 2021-07-29 US disclosed
US-20210101904-A1 PRC2 INHIBITORS Mirati Therapeutics, Inc. 2021-04-08 US disclosed
US-20210032252-A1 PRC2 Inhibitors Mirati Therapeutics, Inc. 2021-02-04 US disclosed
US-9925528-B2 Catalyst-controlled aliphatic C—H oxidations THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2018-03-27 US disclosed
US-9925528-B2 Catalyst-controlled aliphatic C—H oxidations THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2018-03-27 US disclosed
US-9925528-B2 Catalyst-controlled aliphatic C—H oxidations THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2018-03-27 US disclosed
WO-2017162611-A1 QUINOLINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE IN TREATING CANCER ASTRAZENECA AB (SE) 2017-09-28 WO disclosed
WO-2017162611-A1 QUINOLINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE IN TREATING CANCER ASTRAZENECA AB (SE) 2017-09-28 WO disclosed
EP-2864318-B1 2-AMINOPYRAZINE DERIVATIVES AS CSF-1R KINASE INHIBITORS MACROPHAGE PHARMA LTD (GB) 2017-08-09 EP disclosed
US-20170157118-A1 2-AMINOPYRAZINE DERIVATIVES AS CSF-1 R KINASE INHIBITORS MACROPHAGE PHARMA LIMITED (GB) 2017-06-08 US disclosed
US-9604940-B2 2-aminopyrazine derivatives as CSF-1R kinase inhibitors CHROMA THERAPEUTICS LTD. (GB) 2017-03-28 US disclosed
US-20160214097-A1 CATALYST-CONTROLLED ALIPHATIC C-H OXIDATIONS THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2016-07-28 US disclosed
US-20160214097-A1 CATALYST-CONTROLLED ALIPHATIC C-H OXIDATIONS THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2016-07-28 US disclosed
US-20160214097-A1 CATALYST-CONTROLLED ALIPHATIC C-H OXIDATIONS THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2016-07-28 US disclosed
US-20150368210-A1 2-AMINOPYRAZINE DERIVATIVES AS CSF-1 R KINASE INHIBITORS CHROMA THERAPEUTICS LTD. (GB) 2015-12-24 US disclosed
WO-2015035412-A1 CATALYST-CONTROLLED ALIPHATIC C-H OXIDATIONS THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2015-03-12 WO disclosed
WO-2015035412-A1 CATALYST-CONTROLLED ALIPHATIC C-H OXIDATIONS THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2015-03-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11091495-B2 Substituted imidazo[1,2-c]pyrimidines as PRC2 inhibitors EZH2, BMI1, SUZ12 DGAT1 2877/4885FFAR1 3582/4885LPL 3662/4885
US-20160214097-A1 CATALYST-CONTROLLED ALIPHATIC C-H OXIDATIONS HMOX1, SOD3, CYC1 DGAT1 3385/4885FFAR1 3709/4885LPL 3054/4885
US-20170157118-A1 2-AMINOPYRAZINE DERIVATIVES AS CSF-1 R KINASE INHIBITORS CSF1R, CSF3R, FLT3 DGAT1 4513/4885FFAR1 660/4885LPL 4375/4885
US-20230137025-A1 SUBSTITUTED IMIDAZO[1,2-c]PYRIMIDINES AS PRC2 INHIBITORS EZH2, BMI1, SUZ12 DGAT1 2584/4885FFAR1 3892/4885LPL 3655/4885
US-11220509-B2 Substituted imidazo[1,2-c]pyrimidines as PRC2 inhibitors EZH2, BMI1, SUZ12 DGAT1 3239/4885FFAR1 3595/4885LPL 3061/4885
US-20210101904-A1 PRC2 INHIBITORS EZH2, BMI1, SUZ12 DGAT1 1231/4885FFAR1 3959/4885LPL 2258/4885
US-20150368210-A1 2-AMINOPYRAZINE DERIVATIVES AS CSF-1 R KINASE INHIBITORS CSF1R, CSF3R, FLT3 DGAT1 4513/4885FFAR1 660/4885LPL 4375/4885
US-20210032252-A1 PRC2 Inhibitors EZH2, BMI1, SUZ12 DGAT1 1231/4885FFAR1 3959/4885LPL 2258/4885
US-20210230168-A1 PRC2 INHIBITORS EZH2, BMI1, SUZ12 DGAT1 1231/4885FFAR1 3959/4885LPL 2258/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.