Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BIRC3 | Q13489 | 3/20 | 0.38 |
| ▸ | XIAP | P98170 | 2/20 | 0.38 |
| ▸ | BIRC2 | Q13490 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TERF2 | Q15554 | 2/20 | 0.35 |
| ▸ | PPIA | P62937 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1645089 | 0.89 | F2 (0.37) | BIRC3XIAPBIRC2F2F10 | |
| SCHEMBL6382019 | 0.85 | F2 (0.37) | BIRC3XIAPBIRC2F2F10 | |
| SCHEMBL8249384 | 0.85 | F2 (0.37) | BIRC3XIAPBIRC2F2F10 | |
| SCHEMBL8220355 | 0.83 | BIRC3 (0.37) | BIRC3XIAPBIRC2HDAC4HDAC1 | |
| SCHEMBL16349811 | 0.82 | F2 (0.42) | BIRC3XIAPBIRC2F2F10 | |
| SCHEMBL8019153 | 0.82 | GAA (0.35) | F2F10PRSS1ITGB1ITGA4 | |
| SCHEMBL8291443 | 0.81 | F2 (0.43) | BIRC3XIAPBIRC2F2F10 | |
| SCHEMBL14031132 | 0.80 | GAA (0.35) | F2F10PRSS1GAA | |
| SCHEMBL5611990 | 0.80 | RAMP1 (0.34) | — | |
| SCHEMBL1645862 | 0.79 | ADRB3 (0.42) | BIRC3XIAPBIRC2F2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680137-B1 | Macrocyclic carboxylic acid and acylsulfonamide compound as inhibitor of HCV replication | HOFFMANN LA ROCHE (CH) | 2012-11-21 | — | — | EP | disclosed |
| EP-2305698-A2 | Macrocyclic inhibitors of Hepatitis C virus replication | Intermune, Inc. (US) | 2011-04-06 | — | — | EP | disclosed |