Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TGM6 | O95932 | 1/20 | 0.51 |
| ▸ | F13A1 | P00488 | 1/20 | 0.51 |
| ▸ | TGM2 | P21980 | 1/20 | 0.51 |
| ▸ | TGM1 | P22735 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16562287 | 0.98 | RAB9A (0.60) | ALDH1A1RAB9ANPC1SMN1; SMN2POLB | |
| SCHEMBL16562282 | 0.95 | ALDH1A1 (0.60) | ALDH1A1RAB9ANPC1SMN1; SMN2POLB | |
| SCHEMBL16562224 | 0.88 | ALDH1A1 (0.66) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL16562132 | 0.84 | ALDH1A1 (0.62) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL16562274 | 0.84 | ALDH1A1 (0.62) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL16562078 | 0.84 | PLK1 (0.62) | ALDH1A1RAB9ANPC1SMN1; SMN2CYP1A2 | |
| SCHEMBL16562211 | 0.83 | ALDH1A1 (0.64) | ALDH1A1RAB9ANPC1SMN1; SMN2POLB | |
| SCHEMBL16562197 | 0.83 | MAPT (0.62) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL16562206 | 0.83 | ALDH1A1 (0.60) | ALDH1A1RAB9ANPC1SMN1; SMN2CYP1A2 | |
| SCHEMBL16562070 | 0.82 | FPR2 (0.69) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9789096-B2 | Methods and compositions for selective and targeted cancer therapy | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-10-17 | — | — | US | disclosed |
| US-20160200695-A1 | Methods and Compositions for Selective and Targeted Cancer Therapy | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2016-07-14 | — | — | US | disclosed |
| WO-2015035051-A1 | METHODS AND COMPOSITIONS FOR SELECTIVE AND TARGETED CANCER THERAPY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-03-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160200695-A1 | Methods and Compositions for Selective and Targeted Cancer Therapy | NCOA4, SREBF1, ACOX1 | ALDH1A1 88/4885RAB9A 4781/4885NPC1 840/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.