Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.55 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.55 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.55 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16562105 | 0.99 | ALDH1A1 (0.72) | ALDH1A1SMN1; SMN2PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL16562149 | 0.90 | MAPT (0.58) | ALDH1A1SMN1; SMN2PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL16562272 | 0.88 | FKBP1A (0.63) | ALDH1A1SMN1; SMN2PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL16562188 | 0.83 | NAMPT (0.63) | SMN1; SMN2PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL17919369 | 0.82 | SMN1; SMN2 (0.77) | ALDH1A1SMN1; SMN2PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL16562113 | 0.82 | SMN1; SMN2 (0.56) | ALDH1A1SMN1; SMN2PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL28630343 | 0.82 | GLA (0.58) | ALDH1A1SMN1; SMN2GLAKMT2APOLB | |
| SCHEMBL16562143 | 0.81 | NAMPT (0.58) | ALDH1A1SMN1; SMN2PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL10516281 | 0.78 | SMN1; SMN2 (0.71) | ALDH1A1SMN1; SMN2PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL17117344 | 0.77 | SMN1; SMN2 (0.57) | SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9789096-B2 | Methods and compositions for selective and targeted cancer therapy | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-10-17 | — | — | US | disclosed |
| US-9789096-B2 | Methods and compositions for selective and targeted cancer therapy | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-10-17 | — | — | US | disclosed |
| US-20160200695-A1 | Methods and Compositions for Selective and Targeted Cancer Therapy | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2016-07-14 | — | — | US | disclosed |
| US-20160200695-A1 | Methods and Compositions for Selective and Targeted Cancer Therapy | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2016-07-14 | — | — | US | disclosed |
| WO-2015035051-A1 | METHODS AND COMPOSITIONS FOR SELECTIVE AND TARGETED CANCER THERAPY | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-03-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160200695-A1 | Methods and Compositions for Selective and Targeted Cancer Therapy | NCOA4, SREBF1, ACOX1 | ALDH1A1 88/4885SMN1; SMN2 3069/4885PLAAT3 684/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.