Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.58 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16566264 | 0.95 | PDK2 (0.53) | PDK2PDK4ALDH1A1KMT2APOLB | |
| SCHEMBL19411766 | 0.91 | POLB (0.49) | PDK2PDK4ALDH1A1KMT2APOLB | |
| SCHEMBL15499981 | 0.75 | PDK2 (0.50) | PDK2PDK4ALDH1A1KMT2APOLB | |
| SCHEMBL29378958 | 0.75 | PDK2 (0.64) | PDK2PDK4ALDH1A1KMT2AMEN1 | |
| SCHEMBL29988325 | 0.75 | PDK2 (0.64) | PDK2PDK4ALDH1A1KMT2AMEN1 | |
| SCHEMBL2313521 | 0.75 | PDK2 (0.64) | PDK2PDK4ALDH1A1KMT2AMEN1 | |
| SCHEMBL2313523 | 0.75 | PDK2 (0.64) | PDK2PDK4ALDH1A1KMT2AMEN1 | |
| SCHEMBL2313519 | 0.75 | PDK2 (0.64) | PDK2PDK4ALDH1A1KMT2AMEN1 | |
| SCHEMBL16566108 | 0.74 | IDO1 (0.64) | PDK2PDK4ALDH1A1KMT2APOLB | |
| SCHEMBL319934 | 0.74 | PDK2 (1.00) | PDK2PDK4ALDH1A1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041821-B1 | BICYLIC COMPOUNDS AS MODULATORS OF RORGAMMA | BOEHRINGER INGELHEIM INT (DE) | 2018-05-30 | — | — | EP | disclosed |
| US-9745267-B2 | Compounds as modulators of RORC | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-08-29 | — | — | US | disclosed |
| US-20160251310-A1 | COMPOUNDS AS MODULATORS OF RORC | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-09-01 | — | — | US | disclosed |
| WO-2015035032-A1 | BICYLIC COMPOUNDS AS MODULATORS OF RORGAMMA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-03-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160251310-A1 | COMPOUNDS AS MODULATORS OF RORC | RORC, RORB, RORA | PDK2 1781/4885PDK4 1738/4885ALDH1A1 131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.