Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 2/20 | 0.35 |
| ▸ | GABRD | O14764 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.35 |
| ▸ | GABRE | P78334 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15360321 | 0.87 | KDM4E (0.41) | MAPK1CYP2C19KDM4EL3MBTL1MEN1 | |
| SCHEMBL16583121 | 0.87 | MAPK1 (0.39) | MAPK1KDM4EL3MBTL1MEN1KMT2A | |
| SCHEMBL992080 | 0.83 | MAPK1 (0.50) | MAPK1CYP2C19KDM4EL3MBTL1LCK | |
| SCHEMBL12775521 | 0.80 | MAPK1 (0.49) | MAPK1CYP2C19KDM4EL3MBTL1LCK | |
| SCHEMBL68869 | 0.78 | MAPK1 (0.63) | MAPK1CYP2C19KDM4EL3MBTL1LCK | |
| SCHEMBL15360322 | 0.77 | LMNA (0.43) | KDM4EL3MBTL1MEN1KMT2AGABRP | |
| SCHEMBL27991313 | 0.75 | CYP2C19 (0.35) | CYP2C19KDM4EL3MBTL1MEN1KMT2A | |
| SCHEMBL27991315 | 0.74 | AGBL2 (0.36) | CYP2C19KDM4EL3MBTL1MEN1KMT2A | |
| SCHEMBL25153997 | 0.73 | LCK (0.39) | MAPK1CYP2C19KDM4ELCKGABRP | |
| SCHEMBL15352008 | 0.72 | ALDH1A1 (0.39) | KDM4EL3MBTL1MEN1KMT2AGABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2841423-B1 | METHOD FOR PRODUCING 5-(DIFLUOROMETHYL)PYRAZINE-2-CARBOXILIC ACID AND PRODUCTION INTERMEDIATE THEREOF | EISAI R&D MAN CO LTD (JP) | 2016-11-30 | — | — | EP | disclosed |
| US-9227942-B2 | Method for producing 5-(difluoromethyl)pyrazine-2-carboxylic acid and production intermediate thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-01-05 | — | — | US | disclosed |
| US-20150087836-A1 | METHOD FOR PRODUCING 5-(DIFLUOROMETHYL)PYRAZINE-2-CARBOXILIC ACID AND PRODUCTION INTERMEDIATE THEREOF | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-03-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150087836-A1 | METHOD FOR PRODUCING 5-(DIFLUOROMETHYL)PYRAZINE-2-CARBOXILIC ACID AND PRODUCTION INTERMEDIATE THEREOF | BACE1, BACE2, APP | MAPK1 3767/4885CYP2C19 722/4885KDM4E 660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.