Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15818550 | 0.90 | PDE10A (0.41) | PDE10APIK3CDHTR7ALDH1A1PIK3CG | |
| SCHEMBL16584853 | 0.90 | PDE10A (0.51) | PDE10APIK3CDPIK3R1HTR7ALDH1A1 | |
| SCHEMBL16584915 | 0.90 | PDE10A (0.52) | PDE10APIK3CDPIK3R1HTR7ALDH1A1 | |
| SCHEMBL15817991 | 0.87 | PDE10A (0.47) | PDE10APIK3CDPIK3R1PIK3CGPIK3CA | |
| SCHEMBL15826375 | 0.86 | HTR7 (0.50) | HTR7 | |
| SCHEMBL15819602 | 0.85 | PDE10A (0.48) | PDE10APIK3CDPIK3R1HTR7PIK3R2 | |
| SCHEMBL15819392 | 0.84 | PIK3CD (0.45) | PDE10APIK3CDPIK3R1HTR7PIK3CG | |
| SCHEMBL16584956 | 0.84 | ALDH1A1 (0.48) | PDE10APIK3CDALDH1A1PIK3CG | |
| SCHEMBL15818209 | 0.84 | PDE10A (0.42) | PDE10APIK3CDHTR7ALDH1A1PIK3CG | |
| SCHEMBL16584717 | 0.84 | PDE10A (0.53) | PDE10APIK3CDPIK3R1HTR7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3046563-A1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Calitor Sciences, LLC (US) | 2016-07-27 | — | — | EP | disclosed |
| WO-2015042077-A1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2015-03-26 | — | — | WO | disclosed |