Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 17/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | TGM2 | P21980 | 1/20 | 0.46 |
| ▸ | HPD | P32754 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15818550 | 0.88 | PDE10A (0.41) | HTR7TGM2 | |
| SCHEMBL18076631 | 0.87 | HTR7 (0.55) | HTR7HTR1ADRD2HTR2CHTR2A | |
| SCHEMBL15818186 | 0.87 | HTR7 (0.56) | HTR7HTR1ADRD2HTR2CHTR2A | |
| SCHEMBL16584724 | 0.86 | PDE10A (0.45) | HTR7 | |
| SCHEMBL15818395 | 0.84 | TGM2 (0.39) | HTR7TGM2 | |
| SCHEMBL15819051 | 0.84 | HTR7 (0.45) | HTR7TGM2 | |
| SCHEMBL15818209 | 0.81 | PDE10A (0.42) | HTR7TGM2 | |
| SCHEMBL20081376 | 0.81 | HPD (0.49) | HTR7HTR1ADRD2HTR2CHTR2A | |
| SCHEMBL15818331 | 0.80 | PIK3CD (0.47) | HTR7HTR1ADRD2HTR2CHTR2A | |
| SCHEMBL15819553 | 0.80 | PIK3CD (0.40) | HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935246-A1 | ISOQUINOLINONE OR QUINAZOLINONE PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | Gilead Calistoga LLC (US) | 2015-10-28 | — | — | EP | disclosed |
| WO-2014100767-A1 | ISOQUINOLINONE OR QUINAZOLINONE PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD CALISTOGA LLC (US) | 2014-06-26 | — | — | WO | disclosed |