Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TXN | P10599 | 1/20 | 0.89 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.64 |
| ▸ | APP | P05067 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | CA12 | O43570 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | CA9 | Q16790 | 2/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | KCNH3 | Q9ULD8 | 3/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21645541 | 1.00 | TXN (0.89) | TXNNFKB1APPMAPTMEN1 | |
| SCHEMBL535866 | 0.96 | TXN (0.82) | TXNNFKB1APPMAPTMEN1 | |
| SCHEMBL20511159 | 0.94 | TXN (1.00) | TXNNFKB1APPMAPTMEN1 | |
| SCHEMBL11837292 | 0.89 | NFKB1 (0.78) | TXNNFKB1APPMAPTMEN1 | |
| SCHEMBL1925527 | 0.89 | MEN1 (0.79) | TXNNFKB1APPMAPTMEN1 | |
| SCHEMBL28736406 | 0.87 | TXN (0.70) | TXNNFKB1APPMAPTMEN1 | |
| SCHEMBL1924287 | 0.87 | APP (0.70) | TXNNFKB1APPMAPTMEN1 | |
| SCHEMBL21645364 | 0.83 | GAA (0.68) | TXNNFKB1APPMAPTMEN1 | |
| SCHEMBL13950835 | 0.83 | TXN (0.64) | TXNNFKB1APPMAPTCA1 | |
| SCHEMBL3500246 | 0.83 | NFKB1 (0.69) | TXNNFKB1APPMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240368184-A1 | PIKfyve Inhibitors | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2024-11-07 | — | — | US | disclosed |
| US-12030896-B2 | PIKfyve inhibitors | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2024-07-09 | — | — | US | disclosed |
| US-12030896-B2 | PIKfyve inhibitors | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2024-07-09 | — | — | US | disclosed |
| US-12030896-B2 | PIKfyve inhibitors | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2024-07-09 | — | — | US | disclosed |
| CN-108191774-B | Heterocyclic compound, preparation method and application thereof | 中国药科大学 | 2022-05-24 | — | — | CN | disclosed |
| US-20210139505-A1 | PIKfyve Inhibitors | Sanford Burnham Prebys Medical Discovery Institute | 2021-05-13 | — | — | US | disclosed |
| US-20210139505-A1 | PIKfyve Inhibitors | Sanford Burnham Prebys Medical Discovery Institute | 2021-05-13 | — | — | US | disclosed |
| EP-3817736-A1 | PIKFYVE INHIBITORS | Mayo Foundation for Medical Education and Research (US) | 2021-05-12 | — | — | EP | disclosed |
| WO-2019241787-A9 | NOVEL CYCLIC GMP-AMP SYNTHASE (CGAS) INHIBITORS AND THEIR METHOD OF USE | THE REGENTS OF THE UNIVERSITY OF COLORADO A BODY CORPORATE (US) | 2020-02-06 | — | — | WO | disclosed |
| EP-2152676-B1 | \"TRIAZINE DERIVATIVES, COMPOSITIONS CONTAINING SUCH DERIVATIVES, AND METHODS OF TREATMENT OF CANCER AND AUTOIMMUNE DISEASES USING SUCH DERIVATIVES\ | PROMETIC BIOSCIENCES INC (CA) | 2013-04-03 | — | — | EP | disclosed |
| US-20100129350-A1 | Triazine Derivatives, Compositions Containing Such Derivatives, and Methods of Treatment of Cancer and Autoimmune Diseases Using Such Derivatives | PROMETIC BIOSCIENCES INC. (CA) | 2010-05-27 | — | — | US | disclosed |
| EP-2152676-A1 | \"TRIAZINE DERIVATIVES, COMPOSITIONS CONTAINING SUCH DERIVATIVES, AND METHODS OF TREATMENT OF CANCER AND AUTOIMMUNE DISEASES USING SUCH DERIVATIVES\ | ProMetic BioSciences Inc. (CA) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008131547-A1 | 'TRIAZINE DERIVATIVES, COMPOSITIONS CONTAINING SUCH DERIVATIVES, AND METHODS OF TREATMENT OF CANCER AND AUTOIMMUNE DISEASES USING SUCH DERIVATIVES' | PROMETIC BIOSCIENCES INC. (CA) | 2008-11-06 | — | — | WO | disclosed |
| WO-2008131547-A1 | 'TRIAZINE DERIVATIVES, COMPOSITIONS CONTAINING SUCH DERIVATIVES, AND METHODS OF TREATMENT OF CANCER AND AUTOIMMUNE DISEASES USING SUCH DERIVATIVES' | PROMETIC BIOSCIENCES INC. (CA) | 2008-11-06 | — | — | WO | disclosed |
| US-20080255126-A1 | Inhibitors of post-proline cleaving proteases | FERRING B.V. | 2008-10-16 | — | — | US | disclosed |
| US-7335677-B2 | Inhibitors of dipeptidyl peptidase IV | FERRING B.V. (NL) | 2008-02-26 | — | — | US | disclosed |
| US-20050043299-A1 | Inhibitors of dipeptidyl peptidase iv | FERRING B. V. | 2005-02-24 | — | — | US | disclosed |
| EP-1446116-A1 | INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | FERRING B.V. (NL) | 2004-08-18 | — | — | EP | disclosed |
| WO-2003035057-A1 | INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | FERRING B.V. (NL) | 2003-05-01 | — | — | WO | disclosed |
| US-3931165-A | INSECTICIDES, HERBICIDES | BARER SOL J | 1976-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12030896-B2 | PIKfyve inhibitors | PIKFYVE, PIP4K2B, PIP4K2A | TXN 4109/4885NFKB1 2785/4885APP 4389/4885 |
| US-20210139505-A1 | PIKfyve Inhibitors | PIKFYVE, PIP4K2B, PIP4K2A | TXN 4109/4885NFKB1 2785/4885APP 4389/4885 |
| US-20240368184-A1 | PIKfyve Inhibitors | PIKFYVE, PIP4K2B, PIP4K2A | TXN 4109/4885NFKB1 2785/4885APP 4389/4885 |
| US-20100129350-A1 | Triazine Derivatives, Compositions Containing Such Derivatives, and Methods of Treatment of Cancer and Autoimmune Diseases Using Such Derivatives | FLT3, SETD2, SETD7 | TXN 298/4885NFKB1 1502/4885APP 4726/4885 |
| US-20050043299-A1 | Inhibitors of dipeptidyl peptidase iv | DPP4, DPP9, DPP3 | TXN 1996/4885NFKB1 3877/4885APP 1105/4885 |
| US-20080255126-A1 | Inhibitors of post-proline cleaving proteases | PREP, PEPD, DPP4 | TXN 1923/4885NFKB1 2961/4885APP 379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.