SCHEMBL3500246

SCHEMBL3500246

Clc1ccc(Nc2nc(Cl)nc(Cl)n2)cc1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFKB1 P19838 4/20 0.69
NR1I2 O75469 1/20 0.64
AHR P35869 1/20 0.64
TXN P10599 1/20 0.63
MEN1 O00255 4/20 0.63
KMT2A Q03164 4/20 0.63
MAPT P10636 3/20 0.63
MAPK1 P28482 1/20 0.63
CA12 O43570 1/20 0.59
CA1 P00915 1/20 0.59
CA2 P00918 1/20 0.59
CA9 Q16790 1/20 0.59
CA14 Q9ULX7 1/20 0.59
SMN1; SMN2 Q16637 1/20 0.58
KDM4E B2RXH2 2/20 0.58
POLB P06746 3/20 0.55
ALDH1A1 P00352 1/20 0.55
LMNA P02545 1/20 0.53
CHRNA7 P36544 1/20 0.53
ADORA3 P0DMS8 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9390360 0.95 MAPT (0.69) NFKB1NR1I2AHRTXNMEN1
SCHEMBL11837292 0.93 NFKB1 (0.78) NFKB1NR1I2AHRTXNMEN1
SCHEMBL11630110 0.88 KCNH3 (0.59) NFKB1NR1I2AHRTXNMEN1
SCHEMBL3499751 0.88 MAPT (0.85) NFKB1NR1I2AHRTXNMEN1
SCHEMBL11788144 0.86 LMNA (0.74) NFKB1NR1I2AHRTXNMEN1
SCHEMBL23643402 0.83 NFKB1 (0.92) NFKB1TXNMEN1KMT2AMAPT
SCHEMBL8972835 0.83 NFKB1 (0.64) NFKB1NR1I2AHRTXNMEN1
SCHEMBL1658574 0.83 TXN (0.89) NFKB1TXNMEN1KMT2AMAPT
SCHEMBL21645541 0.83 TXN (0.89) NFKB1TXNMEN1KMT2AMAPT
SCHEMBL1391141 0.83 NFKB1 (0.64) NFKB1NR1I2AHRTXNMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5561131-A INCREASING THE WOOL GROWTH BY ADMINISTERING AN ANTIPROTOZOA AGENT TO SHEEP MALLINCKRODT VETERINARY, INC. (US) 1996-10-01 US claimed
EP-0661976-A1 DEFAUNATION METHOD MALLINCKRODT VETERINARY LIMITED (AU) 1995-07-12 EP claimed
EP-0661976-A4 DEFAUNATION METHOD. MALLINCKRODT VETERINARY LTD (AU) 1994-07-20 EP claimed
WO-1993002680-A1 DEFAUNATION METHOD PITMAN-MOORE AUSTRALIA LIMITED (AU) 1993-02-18 WO claimed
WO-2024206939-A2 SARS-COV-2 ENTRY INHIBITORS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2024-10-03 WO disclosed
WO-2018175958-A1 THIOREDOXIN MODULATORS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-09-27 WO disclosed
WO-2016036847-A9 SYNTHETIC POLYMERS AND METHODS OF MAKING AND USING THE SAME BATTELLE MEMORIAL INSTITUTE (US) 2017-04-20 WO disclosed
US-20170088671-A1 SYNTHETIC POLYMERS AND METHODS OF MAKING AND USING THE SAME BATTELLE MEMORIAL INSTITUTE (US) 2017-03-30 US disclosed
US-20170088671-A1 SYNTHETIC POLYMERS AND METHODS OF MAKING AND USING THE SAME BATTELLE MEMORIAL INSTITUTE (US) 2017-03-30 US disclosed
US-9562137-B2 Synthetic polymers and methods of making and using the same BATTELLE MEMORIAL INSTITUTE (US) 2017-02-07 US disclosed
US-9562137-B2 Synthetic polymers and methods of making and using the same BATTELLE MEMORIAL INSTITUTE (US) 2017-02-07 US disclosed
US-20160257785-A1 SYNTHETIC POLYMERS AND METHODS OF MAKING AND USING THE SAME U.S. DEPARTMENT OF ENERGY 2016-09-08 US disclosed
US-4939243-A Water-soluble copper complex disazo compounds containg a chloro triazinylamino group and a group of the vinylsulfone series as fiber-reactive groups and their dyestuffs HOECHST AKTIENGESELLSCHAFT (DE) 1990-07-03 US disclosed
US-4906652-A Azolymethyloxiranes and their use as crop protection agents BASF AKTIENGESELLSCHAFT (DE) 1990-03-06 US disclosed
EP-0258391-A1 USE OF HETEROCYCLIC NITROGEN-CONTAINING COMPOUNDS FOR REDUCING MOISTURE LOSS FROM PLANTS AND INCREASING CROP YIELD RHONE POULENC NEDERLAND B.V. (NL) 1988-03-09 EP disclosed
WO-1987004321-A2 USE OF HETEROCYCLIC NITROGEN-CONTAINING COMPOUNDS FOR REDUCING MOISTURE LOSS FROM PLANTS AND INCREASING CROP YIELD RHONE-POULENC NEDERLANDS B.V. (NL) 1987-07-30 WO disclosed
EP-0084849-B1 WATER SOLUBLE COPPER COMPLEXES OF DISAZO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS DYESTUFFS HOECHST AKTIENGESELLSCHAFT (DE) 1986-05-14 EP disclosed
EP-0084849-A2 Water soluble copper complexes of disazo compounds, process for their preparation and their use as dyestuffs HOECHST AKTIENGESELLSCHAFT (DE) 1983-08-03 EP disclosed
US-3939158-A N-(2,4-dihalo-S-triazin-6-yl)-ureas and process for their manufacture CIBA-GEIGY AG (CH) 1976-02-17 US disclosed
US-3931165-A INSECTICIDES, HERBICIDES BARER SOL J 1976-01-06 US disclosed