Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1659194 | 0.90 | KLKB1 (0.40) | KLKB1MAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL1659330 | 0.90 | POLB (0.40) | KLKB1SMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL1659509 | 0.89 | KLKB1 (0.39) | KLKB1POLB | |
| SCHEMBL1661398 | 0.89 | KLKB1 (0.39) | KLKB1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL1660515 | 0.88 | SCN9A (0.40) | KLKB1RAB9APOLBSCN9A | |
| SCHEMBL1660390 | 0.87 | KLKB1 (0.38) | KLKB1POLBTRPV1SCN9A | |
| SCHEMBL1661096 | 0.86 | KLKB1 (0.37) | KLKB1POLBTRPV1SCN9ATBXA2R | |
| SCHEMBL1659442 | 0.86 | KLKB1 (0.37) | KLKB1POLBTRPV1SCN9A | |
| SCHEMBL1662387 | 0.84 | SCN9A (0.39) | KLKB1MAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL1660378 | 0.84 | MAPT (0.45) | MAPTALDH1A1SMN1; SMN2NPC1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307394-A2 | NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | Amorepacific Corporation (KR) | 2011-04-13 | — | — | EP | disclosed |