Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.50 |
| ▸ | APP | P05067 | 4/20 | 0.45 |
| ▸ | SNCA | P37840 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17958315 | 0.90 | ENPP2 (0.62) | ENPP2APPSNCAMAPTKMT2A | |
| SCHEMBL16596246 | 0.90 | ENPP2 (0.62) | ENPP2APPSNCAMAPTKMT2A | |
| SCHEMBL17971232 | 0.89 | ENPP2 (0.51) | ENPP2APPSNCAMAPTKMT2A | |
| SCHEMBL16596433 | 0.84 | ENPP2 (0.51) | ENPP2APPSNCAMAPTKMT2A | |
| SCHEMBL16596265 | 0.80 | ENPP2 (0.49) | ENPP2APPSNCAMAPTKMT2A | |
| SCHEMBL16596300 | 0.79 | ENPP2 (0.54) | ENPP2APPSNCAMAPTKMT2A | |
| SCHEMBL16596432 | 0.79 | ENPP2 (0.56) | ENPP2APPSNCAMAPTKMT2A | |
| SCHEMBL17958306 | 0.79 | ENPP2 (0.70) | ENPP2APPSNCAMAPTKMT2A | |
| SCHEMBL16596325 | 0.79 | ENPP2 (0.70) | ENPP2APPSNCAMAPTKMT2A | |
| SCHEMBL16591993 | 0.78 | ENPP2 (0.80) | ENPP2APPSNCAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015042053-A1 | VINYL AUTOTAXIN INHIBITOR COMPOUNDS | PHARMAKEA, INC. (US) | 2015-03-26 | — | — | WO | disclosed |
| US-8952016-B2 | Substituted xanthine derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2015-02-10 | — | — | US | disclosed |