Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 3/20 | 0.80 |
| ▸ | APP | P05067 | 3/20 | 0.41 |
| ▸ | SNCA | P37840 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.34 |
| ▸ | PTPN12 | Q05209 | 2/20 | 0.34 |
| ▸ | PTPN22 | Q9Y2R2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17968561 | 0.89 | ENPP2 (1.00) | ENPP2APPSNCAKMT2ATHRB | |
| SCHEMBL17968559 | 0.89 | ENPP2 (1.00) | ENPP2APPSNCAKMT2ATHRB | |
| SCHEMBL16596432 | 0.83 | ENPP2 (0.56) | ENPP2APPSNCAKMT2AMAPT | |
| SCHEMBL16596379 | 0.81 | ENPP2 (0.54) | ENPP2APPSNCAKMT2AMAPT | |
| SCHEMBL16596433 | 0.79 | ENPP2 (0.51) | ENPP2APPSNCAKMT2AMAPT | |
| SCHEMBL16596431 | 0.78 | ENPP2 (0.50) | ENPP2APPSNCAKMT2AMAPT | |
| SCHEMBL16596265 | 0.78 | ENPP2 (0.49) | ENPP2APPSNCAKMT2AMAPT | |
| SCHEMBL17968551 | 0.76 | ENPP2 (0.77) | ENPP2APPSNCAKMT2APOLB | |
| SCHEMBL17968553 | 0.76 | ENPP2 (0.77) | ENPP2APPSNCAKMT2APOLB | |
| SCHEMBL17968554 | 0.75 | ENPP2 (0.74) | ENPP2APPSNCAKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015042052-A1 | HETEROCYCLIC VINYL AUTOTAXIN INHIBITOR COMPOUNDS | PHARMAKEA, INC. (US) | 2015-03-26 | — | — | WO | disclosed |