Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.42 |
| ▸ | PIK3R2 | O00459 | 7/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16597163 | 0.90 | CRHBP (0.45) | PIK3CGPIK3CDPIK3R2HRH3 | |
| SCHEMBL17262976 | 0.88 | PIK3CD (0.44) | PIK3CGPIK3CDPIK3R2 | |
| SCHEMBL16597161 | 0.86 | ALDH1A1 (0.48) | ALDH1A1MEN1LMNAHTTKMT2A | |
| SCHEMBL16584872 | 0.85 | PIK3CD (0.43) | PIK3CGPIK3CDPIK3R2 | |
| SCHEMBL16597162 | 0.85 | HSP90AB1 (0.49) | ALDH1A1MEN1LMNAHTTKMT2A | |
| SCHEMBL21185257 | 0.83 | PIK3CD (0.48) | ALDH1A1MEN1LMNAHTTKMT2A | |
| SCHEMBL22519309 | 0.82 | PIK3CD (0.53) | PIK3CDPIK3R2 | |
| SCHEMBL16584926 | 0.82 | PIK3CD (0.40) | PIK3CGPIK3CDPIK3R2PDE10AHRH3 | |
| SCHEMBL17338310 | 0.82 | PIK3CD (0.49) | ALDH1A1PIK3CDPIK3R2 | |
| SCHEMBL21185248 | 0.81 | ALDH1A1 (0.44) | ALDH1A1MEN1LMNAHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3046563-B1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AS PI3-KINASE INHIBITORS | CALITOR SCIENCES LLC (US) | 2019-05-29 | — | — | EP | disclosed |
| WO-2015042077-A1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2015-03-26 | — | — | WO | disclosed |