Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 2/20 | 0.48 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29056033 | 0.83 | GRM2 (0.47) | GRM2NPC1LMNAPARP1 | |
| SCHEMBL30613366 | 0.82 | NNMT (0.50) | NNMTGPR52MKNK1MKNK2SIRT6 | |
| SCHEMBL7078983 | 0.80 | SYK (0.54) | NNMTGPR52MKNK1MKNK2SIRT6 | |
| SCHEMBL2226625 | 0.77 | GRM2 (0.43) | NNMTGPR52MKNK1MKNK2GRM2 | |
| SCHEMBL28001171 | 0.77 | KDM4E (0.50) | MKNK1MKNK2SIRT6ADORA2APARP1 | |
| SCHEMBL30006999 | 0.76 | KDM4E (0.47) | — | |
| SCHEMBL28492022 | 0.76 | KDM4E (0.47) | — | |
| SCHEMBL30006783 | 0.76 | TDP1 (0.49) | NPC1LMNAPKM | |
| SCHEMBL30006752 | 0.75 | L3MBTL1 (0.46) | KMT2ANPC1LMNAPKM | |
| SCHEMBL16598248 | 0.75 | CYP1A2 (0.41) | MKNK1MKNK2SIRT6ADORA2APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015048503-A2 | N-ARYLMETHYL SULFONAMIDE NEGATIVE MODULATORS OF NR2A | MNEMOSYNE PHARMACEUTICALS, INC. (US) | 2015-04-02 | — | — | WO | disclosed |