SCHEMBL16598583

SCHEMBL16598583

COc1ccc(C(=O)N2CCN(C(=O)/C=C/c3ccc(Br)cc3)CC2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR183 P32249 20/20 1.00
KCNH2 Q12809 3/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16598585 1.00 GPR183 (1.00) GPR183KCNH2
SCHEMBL26093881 0.96 GPR183 (0.93) GPR183KCNH2
SCHEMBL30374883 0.87 GPR183 (0.77) GPR183KCNH2
SCHEMBL16598422 0.86 GPR183 (1.00) GPR183KCNH2
SCHEMBL16598425 0.86 GPR183 (1.00) GPR183KCNH2
SCHEMBL26487595 0.85 GPR183 (0.73) GPR183KCNH2
SCHEMBL26093146 0.85 GPR183 (0.75) GPR183KCNH2
SCHEMBL26089470 0.85 GPR183 (0.73) GPR183KCNH2
SCHEMBL26094471 0.85 GPR183 (0.79) GPR183KCNH2
SCHEMBL16598548 0.84 GPR183 (1.00) GPR183KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4419511-A1 COMPOUNDS AND THEIR USES AS GPR183 INHIBITORS Nanjing Immunophage Biotech Co., Ltd (CN) 2024-08-28 EP claimed
CN-118201911-A Compounds and their use as GPR183 inhibitors 南京艾美斐生物医药科技有限公司 2024-06-14 CN claimed
WO-2023066190-A1 COMPOUNDS AND THEIR USES AS GPR183 INHIBITORS NANJING IMMUNOPHAGE BIOTECH CO., LTD (CN) 2023-04-27 WO claimed
EP-4676918-A1 COMPOUNDS AND THEIR USES AS GPR183 INHIBITORS Nanjing Immunophage Biomedical Co., Ltd. (CN) 2026-01-14 EP disclosed
US-20250034121-A1 COMPOUNDS AND THEIR USES AS GPR183 INHIBITORS NANJING IMMUNOPHAGE BIOMEDICAL CO., LTD. (CN) 2025-01-30 US disclosed
EP-4497440-A1 USE OF 7-TRIFLUOROMETHYL-7ALPHA,25-DIHYDROXYCHOLESTEROL IN THE TREATMENT AND MODULATION OF AUTOIMMUNE AND INFLAMMATORY DISEASES OF THE NERVOUS SYSTEM AND NEURODEGENERATIVE DISEASES Gdanski Uniwersytet Medyczny (PL) 2025-01-29 EP disclosed
WO-2024208303-A1 COMPOUNDS AND THEIR USES AS GPR183 INHIBITORS NANJING IMMUNOPHAGE BIOTECH CO., LTD (CN) 2024-10-10 WO disclosed
WO-2024179405-A1 CLASS OF CINNAMAMIDE DERIVATIVES AND APPLICATION THEREOF 上海交通大学 2024-09-06 WO disclosed
EP-4419511-A1 COMPOUNDS AND THEIR USES AS GPR183 INHIBITORS Nanjing Immunophage Biotech Co., Ltd (CN) 2024-08-28 EP disclosed
CN-118546081-A Cinnamide derivative and application thereof 上海交通大学 2024-08-27 CN disclosed
CN-118201911-A Compounds and their use as GPR183 inhibitors 南京艾美斐生物医药科技有限公司 2024-06-14 CN disclosed
WO-2023066190-A1 COMPOUNDS AND THEIR USES AS GPR183 INHIBITORS NANJING IMMUNOPHAGE BIOTECH CO., LTD (CN) 2023-04-27 WO disclosed
WO-2023066190-A1 COMPOUNDS AND THEIR USES AS GPR183 INHIBITORS NANJING IMMUNOPHAGE BIOTECH CO., LTD (CN) 2023-04-27 WO disclosed
US-9776979-B2 EBI2 modulators SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) 2017-10-03 US disclosed
US-9776979-B2 EBI2 modulators SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) 2017-10-03 US disclosed
US-9776979-B2 EBI2 modulators SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) 2017-10-03 US disclosed
US-20160214951-A1 EBI2 MODULATORS SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE 2016-07-28 US disclosed
US-20160214951-A1 EBI2 MODULATORS SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE 2016-07-28 US disclosed
US-20160214951-A1 EBI2 MODULATORS SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE 2016-07-28 US disclosed
WO-2015048570-A2 EBI2 MODULATORS SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) 2015-04-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160214951-A1 EBI2 MODULATORS BIRC2, HAVCR2, MAVS GPR183 22/4885KCNH2 3147/4885
US-20250034121-A1 COMPOUNDS AND THEIR USES AS GPR183 INHIBITORS GPR183, GPR180, GPR65 GPR183 1/4885KCNH2 2579/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.