Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SLC8A1 | P32418 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1660048 | 0.89 | TRPV1 (0.33) | LMNASMN1; SMN2TRPV1TP53POLB | |
| SCHEMBL1987794 | 0.86 | PDE2A (0.35) | TRPV1 | |
| SCHEMBL12604073 | 0.86 | PDE2A (0.35) | TRPV1 | |
| SCHEMBL1660628 | 0.80 | CES2 (0.40) | LMNASMN1; SMN2TP53POLBALDH1A1 | |
| SCHEMBL1660390 | 0.79 | KLKB1 (0.38) | TRPV1POLBSLC8A1SCN9AKLKB1 | |
| SCHEMBL1659330 | 0.79 | POLB (0.40) | SMN1; SMN2POLBSCN9AKLKB1 | |
| SCHEMBL1659442 | 0.78 | KLKB1 (0.37) | TRPV1POLBSLC8A1SCN9AKLKB1 | |
| SCHEMBL1661096 | 0.78 | KLKB1 (0.37) | TRPV1POLBSLC8A1SCN9AKLKB1 | |
| SCHEMBL12521337 | 0.78 | TRPV1 (0.31) | TRPV1 | |
| SCHEMBL1659194 | 0.77 | KLKB1 (0.40) | SMN1; SMN2TP53POLBSCN9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307394-A2 | NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | Amorepacific Corporation (KR) | 2011-04-13 | — | — | EP | disclosed |