Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16972895 | 0.84 | GABRG2 (0.34) | GABRG2GABRB3GABRA5 | |
| SCHEMBL15743906 | 0.83 | LMNA (0.42) | — | |
| SCHEMBL13340901 | 0.82 | GABRG2 (0.33) | GABRG2GABRB3GABRA5 | |
| SCHEMBL15786403 | 0.81 | MARK3 (0.31) | — | |
| SCHEMBL16601589 | 0.72 | GABRG2 (0.42) | GABRG2GABRB3GABRA5 | |
| SCHEMBL13367734 | 0.71 | CCNC (0.35) | — | |
| SCHEMBL16601593 | 0.69 | BRD4 (0.37) | — | |
| SCHEMBL46323 | 0.69 | GABRA5 (0.46) | GABRG2GABRB3GABRA5 | |
| SCHEMBL46311 | 0.68 | MARK3 (0.36) | — | |
| SCHEMBL16601578 | 0.68 | MAPT (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993585-B2 | Cyclic amine substituted pyrimidinediamines as PKC inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2015-03-31 | — | — | US | disclosed |