Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 2/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13961727 | 0.84 | NR3C2 (0.44) | NR3C2CNR1POLBPDE3BPDE3A | |
| SCHEMBL13367654 | 0.82 | NR3C2 (0.39) | NR3C2OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL13091586 | 0.82 | KDM4E (0.39) | NR3C2OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL13340970 | 0.82 | NR3C2 (0.42) | NR3C2OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL17027192 | 0.82 | NR3C2 (0.42) | NR3C2OPRM1OPRL1ALDH1A1POLB | |
| SCHEMBL13367760 | 0.82 | SLC9A1 (0.40) | NR3C2OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL16601602 | 0.82 | NR3C2 (0.40) | NR3C2KDM4EALDH1A1F2GAA | |
| SCHEMBL17026910 | 0.81 | NR3C2 (0.44) | NR3C2OPRM1OPRL1POLBPDE3B | |
| SCHEMBL15161226 | 0.78 | PDE3B (0.49) | NR3C2KDM4EALDH1A1F2GAA | |
| SCHEMBL16601589 | 0.77 | GABRG2 (0.42) | OPRM1OPRD1OPRK1OPRL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993585-B2 | Cyclic amine substituted pyrimidinediamines as PKC inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2015-03-31 | — | — | US | disclosed |