Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13367654 | 0.90 | NR3C2 (0.39) | NR3C2POLBALDH1A1MAPTKDM4E | |
| SCHEMBL17434459 | 0.85 | ATAD2 (0.44) | NR3C2ALDH1A1MAPTMAPK1TDP1 | |
| SCHEMBL13961731 | 0.85 | NR3C2 (0.39) | NR3C2ALDH1A1HTTKMT2AALPL | |
| SCHEMBL13340973 | 0.83 | NR3C2 (0.38) | NR3C2ALDH1A1MAPTKMT2ATSHR | |
| SCHEMBL16601600 | 0.82 | NR3C2 (0.45) | NR3C2POLBALDH1A1MAPTKDM4E | |
| SCHEMBL17434319 | 0.81 | MAPT (0.39) | NR3C2POLBALDH1A1MAPTTDP1 | |
| SCHEMBL13367651 | 0.80 | RXRA (0.43) | NR3C2POLBALDH1A1MAPTMAPK1 | |
| SCHEMBL17434414 | 0.80 | ATAD2 (0.46) | NR3C2ALDH1A1MAPTMAPK1TDP1 | |
| SCHEMBL16601592 | 0.79 | KMT2A (0.38) | POLBALDH1A1MAPTMAPK1TDP1 | |
| SCHEMBL13367760 | 0.78 | SLC9A1 (0.40) | NR3C2POLBALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993585-B2 | Cyclic amine substituted pyrimidinediamines as PKC inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2015-03-31 | — | — | US | disclosed |