Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | NOS2 | P35228 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3844597 | 0.82 | LTA4H (0.59) | HTTALDH1A1RAB9ALTA4HPDGFRB | |
| SCHEMBL11060936 | 0.79 | HTT (0.55) | HTTALDH1A1LTA4HHDAC4HDAC1 | |
| SCHEMBL13960956 | 0.79 | HTT (0.50) | HTTALDH1A1LTA4HPDGFRBPDGFRA | |
| SCHEMBL14808808 | 0.79 | HTT (0.50) | HTTALDH1A1LTA4HPDGFRBPDGFRA | |
| SCHEMBL4250052 | 0.78 | KMT2A (0.59) | HTTALDH1A1RAB9APDGFRBPDGFRA | |
| SCHEMBL13341001 | 0.78 | HTT (0.50) | HTTALDH1A1LTA4HPDGFRBPDGFRA | |
| SCHEMBL28697805 | 0.77 | HDAC4 (0.54) | HTTALDH1A1LTA4HPDGFRBPDGFRA | |
| SCHEMBL4740818 | 0.76 | AURKA (0.65) | HTTALDH1A1PDGFRBPDGFRAHDAC4 | |
| SCHEMBL1924100 | 0.76 | HTT (0.78) | HTTALDH1A1LTA4HMAPT | |
| SCHEMBL3632606 | 0.75 | ADRA2A (0.50) | HDAC1LMNAMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538084-B1 | PHENYL AND PYRIDINYL HYDROXAMIC ACIDS | ACETYLON PHARMACEUTICALS INC (US) | 2023-11-01 | — | — | EP | disclosed |
| US-8993585-B2 | Cyclic amine substituted pyrimidinediamines as PKC inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2015-03-31 | — | — | US | disclosed |