Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437345 | 0.89 | RAB9A (0.50) | RAB9ANPC1L3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2054548 | 0.87 | RAB9A (0.49) | RAB9ANPC1L3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1519184 | 0.87 | RAB9A (0.49) | RAB9ANPC1L3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1107089 | 0.87 | RAB9A (0.49) | RAB9ANPC1L3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL24121618 | 0.83 | RAB9A (0.46) | RAB9ANPC1L3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7436303 | 0.82 | RAB9A (0.50) | RAB9ANPC1L3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1519333 | 0.82 | CYP4F2 (0.50) | RAB9ANPC1L3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL9256424 | 0.81 | KDM4E (0.53) | RAB9ANPC1SMN1; SMN2NISCHPOLB | |
| SCHEMBL25370326 | 0.81 | CA2 (0.50) | RAB9ANPC1SMN1; SMN2ALDH1A1NISCH | |
| SCHEMBL1519098 | 0.81 | RAB9A (0.49) | RAB9ANPC1L3MBTL1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993585-B2 | Cyclic amine substituted pyrimidinediamines as PKC inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2015-03-31 | — | — | US | disclosed |