SCHEMBL16601667

SCHEMBL16601667

CCC(CN)N1C(=O)c2ccc3c4c(ccc(c24)C1=O)C(=O)N(c1ccccc1)C3=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.46
KDM4E B2RXH2 5/20 0.46
KMT2A Q03164 4/20 0.46
USP2 O75604 3/20 0.46
MAPT P10636 2/20 0.46
HTT P42858 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
KEAP1 Q14145 1/20 0.46
NFE2L2 Q16236 1/20 0.46
MEN1 O00255 3/20 0.43
POLB P06746 4/20 0.41
TDP1 Q9NUW8 2/20 0.41
HPGD P15428 2/20 0.41
APOBEC3A P31941 1/20 0.41
RECQL P46063 1/20 0.41
CASP6 P55212 1/20 0.41
APOBEC3G Q9HC16 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2C19 P33261 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16601638 0.86 KMT2A (0.46) ALDH1A1KDM4EKMT2AUSP2MAPT
SCHEMBL16601637 0.86 POLB (0.44) ALDH1A1KDM4EKMT2AUSP2MAPT
SCHEMBL16601988 0.78 ALDH1A1 (0.48) ALDH1A1KDM4EKMT2AUSP2MEN1
SCHEMBL12382279 0.77 TERT (0.41) ALDH1A1KDM4EKMT2AUSP2HTT
SCHEMBL31167971 0.76 POLB (0.63) ALDH1A1KDM4EKMT2AUSP2MAPT
SCHEMBL7491321 0.76 POLB (0.63) ALDH1A1KDM4EKMT2AUSP2MAPT
SCHEMBL21693567 0.76 POLB (0.45) ALDH1A1KDM4EKMT2AUSP2KEAP1
SCHEMBL13923576 0.75 ALDH1A1 (0.41) ALDH1A1KDM4EKMT2APOLBTDP1
SCHEMBL16601635 0.75 ALDH1A1 (0.43) ALDH1A1KDM4EKMT2AUSP2MAPT
SCHEMBL21693564 0.75 NPC1 (0.47) ALDH1A1KDM4EKMT2AUSP2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9012112-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-04-21 US disclosed
US-9012112-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-04-21 US disclosed
US-8993205-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-03-31 US disclosed
US-8993205-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-03-31 US disclosed