SCHEMBL16601746

SCHEMBL16601746

COc1ccc(-c2ccc3c(c2)C(=Nc2ccc(CCO)cc2)c2ccccc2-3)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.40
TTR P02766 2/20 0.40
MAPT P10636 2/20 0.40
FFAR1 O14842 1/20 0.40
FFAR4 Q5NUL3 1/20 0.40
GAA P10253 1/20 0.40
LRRK2 Q5S007 1/20 0.40
MAOB P27338 4/20 0.40
ABL1 P00519 1/20 0.40
ABCB1 P08183 1/20 0.40
BCR P11274 1/20 0.40
MEN1 O00255 1/20 0.39
POLB P06746 1/20 0.39
KMT2A Q03164 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
BACE1 P56817 1/20 0.39
HDAC4 P56524 1/20 0.39
HDAC2 Q92769 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
PDK2 Q15119 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16601704 0.84 LRRK2 (0.40) ALDH1A1MAPTGAALRRK2MEN1
SCHEMBL16601723 0.82 ALDH1A1 (0.45) ALDH1A1TTRMAPTGAALRRK2
SCHEMBL16656210 0.82 ALDH1A1 (0.45) ALDH1A1TTRMAPTGAALRRK2
SCHEMBL16601705 0.81 ALDH1A1 (0.40) ALDH1A1FFAR1FFAR4MAOBPDK2
SCHEMBL28420499 0.76 ALDH1A1 (0.68) ALDH1A1TTRMAPTGAALRRK2
SCHEMBL8710179 0.75 MAOB (0.66) MAOBMAPK1SMN1; SMN2
Benzene SCHEMBL29206291 0.70 LTA4H (0.57) MAOBMEN1KMT2ASMN1; SMN2
SCHEMBL77472 0.70 TAAR1 (0.61) MAOBTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL31497794 0.68 TAAR1 (0.59) MAOBTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL378856 0.68 ABL1 (0.58) MAOBABL1ABCB1BCRMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9012112-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-04-21 US disclosed
US-9012112-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-04-21 US disclosed
US-8993205-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-03-31 US disclosed
US-8993205-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-03-31 US disclosed