SCHEMBL16601975

SCHEMBL16601975

N#CC(C#N)=C1C(=O)c2cc(-c3ccc(O)cc3)cnc2-c2ncccc21

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
USP7 Q93009 3/20 0.38
TDP2 O95551 1/20 0.38
NSD2 O96028 1/20 0.38
ABL1 P00519 1/20 0.38
PLCG1 P19174 1/20 0.38
CES1 P23141 1/20 0.38
PAX8 Q06710 1/20 0.38
RIN1 Q13671 1/20 0.38
GAA P10253 1/20 0.38
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
NPC1 O15118 1/20 0.37
HPGDS O60760 1/20 0.37
MAPT P10636 1/20 0.37
PKM P14618 1/20 0.37
MAOB P27338 1/20 0.37
RAB9A P51151 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
FYN P06241 2/20 0.36
MAP4K4 O95819 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16601977 0.90 USP7 (0.43) USP7TDP2MEN1KMT2ANPC1
SCHEMBL16656342 0.85 TDP2 (0.40) TDP2NSD2ABL1PLCG1CES1
SCHEMBL16601733 0.84 TDP2 (0.56) USP7TDP2NSD2ABL1PLCG1
SCHEMBL13302011 0.81 TDP2 (0.58) TDP2NSD2ABL1PLCG1CES1
SCHEMBL16602054 0.81 TDP2 (0.40) USP7TDP2NSD2ABL1PLCG1
SCHEMBL16601684 0.76 USP7 (0.56) USP7MEN1KMT2ANPC1HPGDS
SCHEMBL13302054 0.76 TDP2 (0.45) TDP2NSD2ABL1PLCG1CES1
SCHEMBL16601992 0.75 MAPT (0.45) TDP2NSD2GAAMEN1KMT2A
SCHEMBL16601990 0.74 MAPT (0.51) USP7TDP2NSD2GAAMEN1
SCHEMBL12589660 0.73 GAA (0.47) TDP2NSD2ABL1PLCG1CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9012112-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-04-21 US disclosed
US-8993205-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-03-31 US disclosed