SCHEMBL13302011

SCHEMBL13302011

N#CC(C#N)=C1C(=O)c2cccnc2-c2ncccc21

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP2 O95551 4/20 0.58
NSD2 O96028 3/20 0.58
PAX8 Q06710 3/20 0.58
ABL1 P00519 1/20 0.58
PLCG1 P19174 1/20 0.58
CES1 P23141 1/20 0.58
RIN1 Q13671 1/20 0.58
GAA P10253 1/20 0.58
PTPRC P08575 2/20 0.49
CTSL P07711 1/20 0.49
CTSS P25774 1/20 0.49
PTPN13 Q12923 1/20 0.49
MEN1 O00255 1/20 0.48
THRB P10828 1/20 0.48
BLM P54132 1/20 0.48
KMT2A Q03164 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
S100A4 P26447 6/20 0.46
CDC25B P30305 4/20 0.46
PADI1 Q9ULC6 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12589660 0.88 GAA (0.47) TDP2NSD2PAX8ABL1PLCG1
SCHEMBL13302054 0.85 TDP2 (0.45) TDP2NSD2PAX8ABL1PLCG1
SCHEMBL16602054 0.83 TDP2 (0.40) TDP2NSD2PAX8ABL1PLCG1
SCHEMBL13302012 0.82 TDP2 (0.42) TDP2NSD2PAX8ABL1PLCG1
SCHEMBL16601975 0.81 USP7 (0.38) TDP2NSD2PAX8ABL1PLCG1
SCHEMBL13292080 0.80 TDP2 (0.50) TDP2NSD2PAX8ABL1PLCG1
SCHEMBL27348247 0.80 PTPRC (0.46) TDP2NSD2PAX8ABL1PLCG1
SCHEMBL16656342 0.80 TDP2 (0.40) TDP2NSD2PAX8ABL1PLCG1
SCHEMBL8813969 0.79 PTPRC (0.47) TDP2NSD2PAX8ABL1PLCG1
SCHEMBL20779033 0.79 TDP2 (0.38) TDP2NSD2PAX8ABL1PLCG1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7745083-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2010-06-29 US disclosed
US-20090297218-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2009-12-03 US disclosed
US-7592113-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2009-09-22 US disclosed
US-20080233499-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2008-09-25 US disclosed
US-7396622-B2 Having a charge generation layer containing a phenanthrene compound, a phenanthroline compound or an acenaphthene compound that has two oxo-, phenylimino- or dicyanovinylene groups that may be the same or different; charge-generating material is preferably hydroxygallium phthalocyanine. CANON KABUSHIKI KAISHA (JP) 2008-07-08 US disclosed