SCHEMBL16603392

SCHEMBL16603392

Cc1ccc(COc2ccc(-c3ccc(C)cc3)cc2)cc1

nearest known ligand 0.62

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.62
NPC1 O15118 3/20 0.61
RAB9A P51151 3/20 0.61
PARP10 Q53GL7 1/20 0.61
CASP3 P42574 1/20 0.59
SMN1; SMN2 Q16637 1/20 0.59
SENP8 Q96LD8 1/20 0.59
SENP7 Q9BQF6 1/20 0.59
SENP6 Q9GZR1 1/20 0.59
ALDH1A1 P00352 1/20 0.57
MAPT P10636 1/20 0.57
MAPK1 P28482 1/20 0.57
HRH3 Q9Y5N1 1/20 0.57
APP P05067 4/20 0.54
FFAR1 O14842 1/20 0.52
GSTP1 P09211 1/20 0.51
AGXT P21549 1/20 0.50
HPGD P15428 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12918621 1.00 MAOB (0.62) MAOBNPC1RAB9APARP10CASP3
SCHEMBL18635916 1.00 MAOB (0.62) MAOBNPC1RAB9APARP10CASP3
SCHEMBL1702909 1.00 MAOB (0.62) MAOBNPC1RAB9APARP10CASP3
SCHEMBL8929713 0.93 MAOB (0.69) MAOBNPC1RAB9APARP10CASP3
SCHEMBL891195 0.93 MAOB (0.69) MAOBNPC1RAB9APARP10CASP3
SCHEMBL762195 0.93 MAOB (0.69) MAOBNPC1RAB9APARP10CASP3
SCHEMBL8930213 0.93 MAOB (0.69) MAOBNPC1RAB9APARP10CASP3
SCHEMBL12885558 0.92 MAOB (0.56) MAOBNPC1RAB9APARP10CASP3
SCHEMBL14864480 0.92 GSTP1 (0.63) MAOBNPC1RAB9APARP10CASP3
SCHEMBL260484 0.91 MAOB (0.58) MAOBNPC1RAB9APARP10CASP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10988692-B2 Liquid crystal medium and liquid crystal device MERCK PATENT GMBH (DE) 2021-04-27 US disclosed
US-20200248077-A1 LIQUID CRYSTAL MEDIUM AND LIQUID CRYSTAL DEVICE MERCK PATENT GMBH (DE) 2020-08-06 US disclosed
US-10711196-B2 Bimesogenic compounds and mesogenic media MERCK PATENT GMBH (DE) 2020-07-14 US disclosed
US-20200181492-A1 LIQUID CRYSTAL MEDIUM AND LIQUID CRYSTAL DEVICE MERCK PATENT GMBH (DE) 2020-06-11 US disclosed
US-10669484-B2 Process of preparing a light modulation element MERCK PATENT GMBH (DE) 2020-06-02 US disclosed
US-10450508-B2 Bimesogenic compounds and mesogenic media MERCK PATENT GMBH (DE) 2019-10-22 US disclosed
US-10392561-B2 Bimesogenic compounds and mesogenic media MERCK PATENT GMBH (DE) 2019-08-27 US disclosed
US-10343982-B2 Compounds and mesogenic media MERCK PATENT GMBH (DE) 2019-07-09 US disclosed
US-10190049-B2 Mesogenic media and liquid crystal display MERCK PATENT GMBH (DE) 2019-01-29 US disclosed
US-20180187081-A1 PROCESS OF PREPARING A LIGHT MODULATION ELEMENT MERCK PATENT GMBH (DE) 2018-07-05 US disclosed
US-20160222293-A1 MESOGENIC COMPOUNDS AND MESOGENIC MEDIA MERCK PATENT GMBH (DE) 2016-08-04 US disclosed
US-20150315470-A1 BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA MERCK PATENT GMBH (DE) 2015-11-05 US disclosed
US-20150210921-A1 BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA MERCK PATENT GMBH (DE) 2015-07-30 US disclosed
US-20150203756-A1 BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA MERCK PATENT GMBH (DE) 2015-07-23 US disclosed
US-20150203755-A1 BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA MERCK PATENT GMBH (DE) 2015-07-23 US disclosed
US-20150203755-A1 BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA MERCK PATENT GMBH (DE) 2015-07-23 US disclosed
US-20150175886-A1 MESOGENIC MEDIA AND LIQUID CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 2015-06-25 US disclosed
US-20150175883-A1 Bimesogenic Compounds and Mesogenic Media MERCK PATENT GMBH (DE) 2015-06-25 US disclosed
US-20150175883-A1 Bimesogenic Compounds and Mesogenic Media MERCK PATENT GMBH (DE) 2015-06-25 US disclosed
US-20150090935-A1 BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA MERCK PATENT GMBH (DE) 2015-04-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10450508-B2 Bimesogenic compounds and mesogenic media SP1, FOXM1, S100A11 MAOB 3238/4885NPC1 2189/4885RAB9A 2884/4885
US-20150210921-A1 BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA SP1, FOXM1, S100A11 MAOB 3274/4885NPC1 2140/4885RAB9A 2745/4885
US-20150175883-A1 Bimesogenic Compounds and Mesogenic Media SP1, FOXM1, S100A11 MAOB 3274/4885NPC1 2140/4885RAB9A 2745/4885
US-20150203756-A1 BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA SP1, FOXM1, S100A11 MAOB 3274/4885NPC1 2140/4885RAB9A 2745/4885
US-10343982-B2 Compounds and mesogenic media MTX1, NEFM, MTX2 MAOB 535/4885NPC1 1714/4885RAB9A 836/4885
US-20150315470-A1 BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA SP1, FOXM1, S100A11 MAOB 3274/4885NPC1 2140/4885RAB9A 2745/4885
US-20150203755-A1 BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA SP1, FOXM1, S100A11 MAOB 3274/4885NPC1 2140/4885RAB9A 2745/4885
US-10392561-B2 Bimesogenic compounds and mesogenic media SP1, FOXM1, S100A11 MAOB 3274/4885NPC1 2140/4885RAB9A 2745/4885
US-10711196-B2 Bimesogenic compounds and mesogenic media BMP2, NEFM, MTX1 MAOB 578/4885NPC1 3539/4885RAB9A 872/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.