Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.57 |
| ▸ | TUBB | P07437 | 1/20 | 0.57 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.57 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.57 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.57 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.57 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.57 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.57 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.57 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.57 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.57 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.57 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1660425 | 1.00 | TNFRSF1A (0.60) | TNFRSF1AKDM4EHPGDALDH1A1KMT2A | |
| SCHEMBL1660427 | 1.00 | TNFRSF1A (0.60) | TNFRSF1AKDM4EHPGDALDH1A1KMT2A | |
| SCHEMBL12793457 | 0.91 | TTR (0.57) | KDM4EHPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL12731782 | 0.91 | MAOB (0.66) | KDM4EHPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL1660732 | 0.90 | MET (0.57) | KDM4EHPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL11903912 | 0.90 | TTR (0.65) | TNFRSF1AKDM4EHPGDALDH1A1KMT2A | |
| SCHEMBL15169491 | 0.90 | FDPS (0.59) | KDM4EHPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL1660735 | 0.90 | MET (0.57) | KDM4EHPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL11903909 | 0.90 | TTR (0.65) | TNFRSF1AKDM4EHPGDALDH1A1KMT2A | |
| SCHEMBL1660737 | 0.90 | MET (0.57) | KDM4EHPGDALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486026-A1 | DERIVATIVES OF DI(PHENYLPROPANOID) GLYCEROL FOR THE TREATMENT OF CANCER | MacGregor, Alexander (CA) | 2012-08-15 | — | — | EP | claimed |
| US-20110086912-A1 | Derivatives of Propane Diyl Dicinnamate | MACGREGOR ALEXANDER | 2011-04-14 | — | — | US | claimed |
| WO-2011041907-A1 | DERIVATIVES OF DI(PHENYLPROPANOID) GLYCEROL FOR THE TREATMENT OF CANCER | MACGREGOR ALEXANDER (CA) | 2011-04-14 | — | — | WO | claimed |
| US-10052301-B2 | Derivatives of propane diyl dicinnamate | ORX PHARMACEUTICAL CORPORATION (CA) | 2018-08-21 | — | — | US | disclosed |
| US-20150246014-A1 | Derivatives of Propane Diyl Dicinnamate | ORX PHARMACEUTICAL CORPORATION (CA) | 2015-09-03 | — | — | US | disclosed |
| US-9061993-B2 | Derivatives of propane diyl dicinnamate | Toronto Institute of Pharmaceutical Technology (CA) | 2015-06-23 | — | — | US | disclosed |
| EP-2486026-A1 | DERIVATIVES OF DI(PHENYLPROPANOID) GLYCEROL FOR THE TREATMENT OF CANCER | MacGregor, Alexander (CA) | 2012-08-15 | — | — | EP | disclosed |
| US-20110086912-A1 | Derivatives of Propane Diyl Dicinnamate | MACGREGOR ALEXANDER | 2011-04-14 | — | — | US | disclosed |
| WO-2011041907-A1 | DERIVATIVES OF DI(PHENYLPROPANOID) GLYCEROL FOR THE TREATMENT OF CANCER | MACGREGOR ALEXANDER (CA) | 2011-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150246014-A1 | Derivatives of Propane Diyl Dicinnamate | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, DECR2, DECR1 | TNFRSF1A 2598/4885KDM4E 1830/4885HPGD 363/4885 |
| US-10052301-B2 | Derivatives of propane diyl dicinnamate | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, DECR2, DECR1 | TNFRSF1A 2598/4885KDM4E 1830/4885HPGD 363/4885 |
| US-20110086912-A1 | Derivatives of Propane Diyl Dicinnamate | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, DECR2, DECR1 | TNFRSF1A 2581/4885KDM4E 1786/4885HPGD 284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.