Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 7/20 | 0.62 |
| ▸ | GAA | P10253 | 5/20 | 0.62 |
| ▸ | MEN1 | O00255 | 8/20 | 0.60 |
| ▸ | HTT | P42858 | 4/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | VCP | P55072 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16607135 | 0.91 | ALDH1A1 (0.76) | KMT2AKDM4EALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL12248866 | 0.87 | KDM4E (0.69) | KMT2AKDM4EATMALDH1A1SMN1; SMN2 | |
| SCHEMBL5731231 | 0.87 | KDM4E (0.69) | KMT2AKDM4EATMALDH1A1SMN1; SMN2 | |
| SCHEMBL16607198 | 0.86 | MAPT (0.81) | KMT2AKDM4EALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL12249036 | 0.86 | KDM4E (0.70) | KMT2AKDM4EATMALDH1A1SMN1; SMN2 | |
| SCHEMBL16607179 | 0.85 | KMT2A (0.69) | KMT2AKDM4EALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL16607184 | 0.85 | ALDH1A1 (0.76) | KMT2AKDM4EALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL16607165 | 0.85 | ABL1 (0.74) | KMT2AKDM4EALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL16607130 | 0.85 | ALDH1A1 (0.79) | KMT2AKDM4EALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL16607163 | 0.85 | ALDH1A1 (0.79) | KMT2AKDM4EALDH1A1SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10729695-B2 | Amino, amido and heterocyclic compounds as modulators of RAGE activity and uses thereof | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2020-08-04 | — | — | US | disclosed |
| US-10265320-B2 | Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2019-04-23 | — | — | US | disclosed |
| US-20160263125-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | NEW YORK UNIVERSITY | 2016-09-15 | — | — | US | disclosed |
| US-9364472-B2 | Amino, Amido and heterocyclic compounds as modulators of RAGE activity and uses thereof | NEW YORK UNIVERSITY (US) | 2016-06-14 | — | — | US | disclosed |
| US-9353078-B2 | Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof | NEW YORK UNIVERSITY (US) | 2016-05-31 | — | — | US | disclosed |
| US-20160101096-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | NEW YORK UNIVERSITY | 2016-04-14 | — | — | US | disclosed |
| WO-2015050984-A1 | AMINO, AMIDO, AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | NEW YORK UNIVERSITY (US) | 2015-04-09 | — | — | WO | disclosed |
| US-20150094307-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | 2015-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150094307-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | AGER, IAPP, GPR119 | KMT2A 4609/4885KDM4E 3803/4885ATM 873/4885 |
| US-10729695-B2 | Amino, amido and heterocyclic compounds as modulators of RAGE activity and uses thereof | AGER, IAPP, GPR119 | KMT2A 4609/4885KDM4E 3803/4885ATM 873/4885 |
| US-20160263125-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | AGER, IAPP, GPR119 | KMT2A 4609/4885KDM4E 3803/4885ATM 873/4885 |
| US-20160101096-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | AGER, IAPP, GPR119 | KMT2A 4609/4885KDM4E 3803/4885ATM 873/4885 |
| US-10265320-B2 | Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof | AGER, IAPP, GPR119 | KMT2A 4609/4885KDM4E 3803/4885ATM 873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.