Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.73 |
| ▸ | MEN1 | O00255 | 6/20 | 0.73 |
| ▸ | NPC1 | O15118 | 1/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | MPL | P40238 | 3/20 | 0.54 |
| ▸ | PHGDH | O43175 | 2/20 | 0.54 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.52 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16607144 | 0.89 | KMT2A (0.78) | KMT2AMEN1NPC1KDM4EMAPT | |
| SCHEMBL16607169 | 0.88 | MAPT (0.67) | KMT2AMEN1NPC1KDM4EMAPT | |
| SCHEMBL16607316 | 0.88 | HTT (0.62) | KMT2AMEN1NPC1KDM4EMAPT | |
| SCHEMBL16607223 | 0.82 | MEN1 (0.77) | KMT2AMEN1NPC1KDM4EMAPT | |
| SCHEMBL16607179 | 0.81 | KMT2A (0.69) | KMT2AMEN1NPC1KDM4EMAPT | |
| SCHEMBL16607221 | 0.80 | KMT2A (0.63) | KMT2AMEN1NPC1KDM4EMAPT | |
| SCHEMBL16607212 | 0.79 | MEN1 (0.67) | KMT2AMEN1KDM4EMAPTMAPK1 | |
| SCHEMBL16607168 | 0.78 | MAPT (0.62) | KMT2AMEN1KDM4EMAPTMAPK1 | |
| SCHEMBL24107407 | 0.77 | KMT2A (0.72) | KMT2AMEN1NPC1KDM4EMAPT | |
| SCHEMBL16607129 | 0.77 | ADORA3 (0.75) | KMT2AMEN1NPC1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10729695-B2 | Amino, amido and heterocyclic compounds as modulators of RAGE activity and uses thereof | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2020-08-04 | — | — | US | disclosed |
| US-10265320-B2 | Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2019-04-23 | — | — | US | disclosed |
| US-20160263125-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | NEW YORK UNIVERSITY | 2016-09-15 | — | — | US | disclosed |
| US-9364472-B2 | Amino, Amido and heterocyclic compounds as modulators of RAGE activity and uses thereof | NEW YORK UNIVERSITY (US) | 2016-06-14 | — | — | US | disclosed |
| US-9353078-B2 | Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof | NEW YORK UNIVERSITY (US) | 2016-05-31 | — | — | US | disclosed |
| US-20160101096-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | NEW YORK UNIVERSITY | 2016-04-14 | — | — | US | disclosed |
| WO-2015050984-A1 | AMINO, AMIDO, AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | NEW YORK UNIVERSITY (US) | 2015-04-09 | — | — | WO | disclosed |
| US-20150094307-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | 2015-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150094307-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | AGER, IAPP, GPR119 | KMT2A 4609/4885MEN1 2624/4885NPC1 4220/4885 |
| US-10729695-B2 | Amino, amido and heterocyclic compounds as modulators of RAGE activity and uses thereof | AGER, IAPP, GPR119 | KMT2A 4609/4885MEN1 2624/4885NPC1 4220/4885 |
| US-20160263125-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | AGER, IAPP, GPR119 | KMT2A 4609/4885MEN1 2624/4885NPC1 4220/4885 |
| US-20160101096-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | AGER, IAPP, GPR119 | KMT2A 4609/4885MEN1 2624/4885NPC1 4220/4885 |
| US-10265320-B2 | Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof | AGER, IAPP, GPR119 | KMT2A 4609/4885MEN1 2624/4885NPC1 4220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.