Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1661537 | 0.72 | GPR55 (0.32) | — | |
| SCHEMBL25371163 | 0.60 | HTR2A (0.60) | HTR2AKMT2ATAAR1 | |
| SCHEMBL4318969 | 0.60 | KMT2A (0.45) | HTR2AKMT2ATAAR1 | |
| SCHEMBL5857702 | 0.59 | LTA4H (0.58) | — | |
| SCHEMBL9161008 | 0.58 | LTA4H (0.42) | KMT2A | |
| SCHEMBL2857779 | 0.57 | SLC6A2 (0.61) | HTR2AKMT2ATAAR1 | |
| SCHEMBL30249073 | 0.57 | KMT2A (0.64) | HTR2AKMT2ATAAR1 | |
| SCHEMBL27298513 | 0.57 | KMT2A (0.56) | HTR2AKMT2ATAAR1 | |
| SCHEMBL14655700 | 0.57 | KMT2A (0.64) | HTR2AKMT2ATAAR1 | |
| SCHEMBL266563 | 0.57 | KMT2A (0.64) | HTR2AKMT2ATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488031-A1 | DIARYL ETHER DERIVATIVES AS NOTCH SPARING GAMMA SECRETASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046774-A1 | DIARYL ETHER DERIVATIVES AS NOTCH SPARING GAMMA SECRETASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-04-21 | — | — | WO | disclosed |