Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.85 |
| ▸ | NPC1 | O15118 | 7/20 | 0.70 |
| ▸ | RAB9A | P51151 | 7/20 | 0.70 |
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.60 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.60 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.60 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12502132 | 0.92 | F2 (1.00) | F2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL10162070 | 0.81 | NPC1 (0.76) | F2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL6360105 | 0.81 | F2 (0.77) | F2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL4575591 | 0.80 | KMT2A (0.68) | F2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL13514038 | 0.79 | NPC1 (0.71) | F2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL30038962 | 0.78 | RAB9A (0.76) | F2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL4507767 | 0.78 | RAB9A (0.76) | F2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL18398690 | 0.78 | RAB9A (0.76) | F2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL28656164 | 0.78 | RAB9A (0.76) | F2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL23406123 | 0.78 | F2 (0.72) | F2NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9624224-B2 | Inhibitors of Bruton's tyrosine kinase | PHARMACYCLICS LLC (US) | 2017-04-18 | — | — | US | disclosed |
| US-20170050970-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. | 2017-02-23 | — | — | US | disclosed |
| US-20150094319-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC | 2015-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050970-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, LYN, LCK | F2 2905/4885NPC1 4476/4885RAB9A 2689/4885 |
| US-20150094319-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, LYN, LCK | F2 2905/4885NPC1 4476/4885RAB9A 2689/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.