Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 17/20 | 0.57 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | TEK | Q02763 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1660380 | 0.84 | NPC1 (0.47) | BRAFP2RY1KDR | |
| SCHEMBL1660113 | 0.84 | MAPK14 (0.51) | BRAFP2RY1KDR | |
| SCHEMBL1659319 | 0.83 | RAF1 (0.45) | BRAFP2RY1NTRK1 | |
| SCHEMBL5880620 | 0.83 | BRAF (0.66) | BRAFKDRTEK | |
| SCHEMBL1662296 | 0.76 | RAF1 (0.64) | BRAFKDRTEK | |
| SCHEMBL1662217 | 0.75 | BRAF (0.68) | BRAFKDR | |
| SCHEMBL2932022 | 0.74 | BRAF (0.71) | BRAFKDR | |
| SCHEMBL2559430 | 0.73 | BRAF (0.72) | BRAFNTRK1KDRTEK | |
| SCHEMBL3759461 | 0.73 | BRAF (1.00) | BRAF | |
| SCHEMBL5899252 | 0.73 | BRAF (0.62) | BRAFP2RY1KDRTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046991-A2 | CERTAIN SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT, INC. (US) | 2011-04-21 | — | — | WO | claimed |